Another candidate
The new drug neutralizes several factors of Alzheimer's disease at once
Sergey Kolenov, Hi-tech+
American scientists have presented a compound that neutralizes several factors involved in the development of Alzheimer's disease at once. Tests on mice have already confirmed its effectiveness.
Article by Cho et al. A Multifunctional Chemical Agent as an Attenuator of Amyloid Burden and Neuroinflammation in Alzheimer's Disease is published in the journal ACS Chemical Neuroscience – VM.
Many researchers associate Alzheimer's disease with the formation of plaques from toxic beta-amyloid proteins in brain neurons. However, experts from the University of Illinois at Urbana-Champaign believe that the process of neurodegeneration begins much earlier, and individual proteins are even more dangerous than their clusters.
According to this hypothesis, the formation of plaques may be an attempt by the body to neutralize the threat posed by toxic proteins. However, other pathogenic proteins – tau - gather around them. They cause inflammation, interfere with the normal functioning of neurons and ultimately lead to their death.
It is possible that another, much less well–known component is involved in the development of Alzheimer's disease - copper, iron and zinc ions, the concentration of which is increased in the brain of many patients with this diagnosis. They can interact with beta-amyloids, making them more stable, as well as stimulate oxidative stress and inflammation of the brain.
The team, whose work is described in the press release of Molecule reduces multiple pathologies associated with Alzheimer's disease, not only found confirmation of the complex hypothesis of the origin of Alzheimer's disease, but also proposed a compound that can neutralize several factors causing it at once. An experimental drug called L1 interacts with both beta-amyloid proteins and metal ions.
Trials involving genetically modified mice predisposed to neurodegeneration confirmed that L1 overcomes the blood-brain barrier, reduces inflammation of neurons and reduces the concentration of amyloid plaques and associated tau proteins.
The authors hope that this compound or its analogues will become the basis for new drugs against Alzheimer's disease.
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