Double blow to cancer: 2-deoxyglucose + Navitoclax

A way to destroy cancer cells with sugar has been foundCopper news
Guy Perkins from the University of California San Diego suggests using a glucose analog to fight malignant cells, which turned out to be toxic for them, reports New Scientist (Cancer cells poisoned with sugar)

with reference to a publication in the journal Cancer Research (Finding a Panacea Among Combination Cancer Therapies – VM).

Perkins' approach is based on the fact that glucose is the source of carbon and energy for cells. Together with his Japanese colleague Rudy Yamaguchi from Kyushu University in Fukuoka, he discovered that cancer cells are able to absorb a synthetic glucose analog 2-deoxyglucose from the external environment.

Once inside the cell, 2-deoxyglucose physically displaces a protein from the metabolic chains, which blocks the mechanism of apoptosis in cancer cells. Normally, apoptosis, or programmed cell death, ensures the suicide of cells that pose a danger to the body. In cancer cells, this process is disrupted, and therefore they divide endlessly. 2-deoxyglucose, depriving cancer cells of the protein that makes them immortal, turns on the mechanism of cellular suicide again.

As Perkins and Yamaguchi have shown, the death of cells that have absorbed 2-deoxyglucose can be caused using the drug AVT-263 (Navitoclax). It is specially designed to suppress the activity of two intracellular apoptosis inhibitors Bcl-2/Bcl-xL.

This approach seems promising for the treatment of lung, liver, breast and blood cancers. In experiments on mice with prostate cancer, the disappearance of aggressive tumors within a few days was shown.

Yamaguchi and Perkins plan to begin clinical trials of the method at the University of California San Diego.

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06.12.2011