Osteoporosis? Block the synthesis of serotonin in the intestine!
Two messages on the same topic:
the first is more authentic and not very clear, but with pictures and jokes, and most importantly – with links to sources;
the second is short and to the point, but without links to a press release and an article in Nature Medicine.
The treatment of bones with serotonin block was inventedMembrane
In people over the age of 20, the balance between bone formation and bone destruction is slowly but steadily shifting for the worse.
Osteoporosis is a disease when the bone mass falls below a certain level, and the bones themselves become brittle and porous. The relationship between serotonin levels and osteoporosis has been studied for a long time and thoroughly. Despite this, until now, science could do little for those unfortunate people whose bones were thinning and collapsing with each passing month.
An international group of scientists led by specialists from Columbia University Medical Center in New York successfully tested a new drug against bone fragility on mice. Blocking the production of serotonin, the drug showed a phenomenal "repair" effect.
During the new experiment, Gerard Karsenty and his colleagues once a day orally gave a small dose of a drug codenamed LP533401 to experimental rodents who suffered. The results were stunning – after six weeks, the animals that had the initial signs of the disease had no trace of them, and even in cases when the mouse was already seriously ill, it was completely cured.
The drug chosen with an eye to recent American studies is aimed primarily at regulating intestinal serotonin production. Despite the fact that this hormone is known primarily as a brain neurotransmitter, the predominant part of it is produced in the intestine, and one of the main functions of serotonin is to prevent excessive bone growth. In the case of a sick organism, the hormone turns from a caring gardener into an executioner and "does not allow" the thinned bone to recover.
Serotonin is produced by enterochromaffin cells of the intestine and enters the blood.
Then the hormone reaches the bone and binds to the Htr1b receptor on its surface, preventing further growth.
Directly responsible for the synthesis of serotonin is the Lrp5 gene in conjunction with the enzyme Tph1 –
this is what the new drug deactivates (illustration by Karsenty et al./Cell).
Even before Karsenti and his team found out about the existence of LP533401, they theoretically calculated that a serotonin synthesis inhibitor substance should be effective in the fight against osteoporosis.
According to scientists, this discovery may give the green light to new treatments focused on restoring already damaged tissues, and not only on preventing the development of the disease (there are currently no safe drugs of this kind).
According to Karsenti, the level of serotonin in the brain did not fluctuate in experimental animals, which means that LP533401 does not cross the blood–brain barrier and can be used "pointwise", which will avoid side effects.
The scientists' article was published in Nature Medicine (it can also be read in PDF format).
Source: ScienceDaily, Inhibiting Serotonin in Gut Could Cure Osteoporosis* * *
The tablet preparation contributed to the cure of mice and rats from osteoporosis
Natalia Pankratova, Farmvestnik, based on Reuters materials:
Daily pill helped cure osteoporosis in mice, ratsThe tablet preparation for taking 1 time a day helped to completely restore bone mineral density in rodents with severe osteoporosis.
According to American researchers, the results of the experiment may be the beginning of the development of a new class of drugs for the treatment of osteoporosis in humans.
A team of researchers from Columbia University Medical Center in New York tested a substance that blocks serotonin synthesis in the intestines of rodents with severe osteoporosis, and found that against the background of taking an experimental substance, the bone density of mice and rats completely recovered.
According to Dr. Gerard Karsenty, representing the team of researchers, "fortunately, there are inhibitors of serotonin synthesized in the intestine that do not affect the process of serotonin synthesis in the brain." He also said that the drug has already been tested in humans as part of the initial stage of safety studies. However, Dr. Karsenti noted, these are still preliminary results and many more tests are required before it will be possible to conduct studies of the drug on people with osteoporosis.
Portal "Eternal youth" http://vechnayamolodost.ru09.02.2010