Polycystic ovaries can be cured
Scientists cured polycystic ovary syndrome in mice
Anna Kerman, XX2 century, based on the materials of IFLScience: Scientists Finally Think They Know What Causes Polycystic Ovary Syndrome – And How To Cure It
Although polycystic ovary syndrome is considered one of the most common gynecological pathologies, the causes of its occurrence have not been completely clear until now.
Polycystic Ovary syndrome (PCOS) – this is a problem that every fifth woman faces. And scientists finally managed to figure out why. The authors of the study, published in Nature Medicine, found a link between hormonal imbalance in the uterus and polycystic fibrosis. Prenatal contact with a growth factor called anti-muller hormone (AMH) turned out to be especially dangerous.
A group of scientists led by Paolo Giacobini from the French National Institute of Health and Medical Research (Institut national de la santé et de la recherche médicale) found that the level of AMH in pregnant women suffering from polycystic ovary syndrome was 30% higher than in women without PCOS. Since this painful condition is considered hereditary, the researchers decided to find out whether women with hormonal imbalance will have daughters suffering from PCOS.
"This is a fundamentally new approach to understanding polycystic ovary syndrome, it opens the door to a number of areas for new research," explains Robert Norman from the University of Adelaide.
As part of the experiment, scientists injected anti-muller hormone into pregnant mice. As a result, females born as a result of this pregnancy developed a condition similar to PCOS in women. Fertility problems were recorded in animals, the onset of puberty was later, and ovulation was irregular.
As follows from the work, the introduction of AMH led to hyperstimulation of a group of brain cells responsible for controlling the level of testosterone in the body. As a result, increased testosterone concentrations were observed in the offspring, and by the time puberty was reached, testosterone–related pathological conditions were also observed, in particular, "masculinization of the female fetus" and "PCOS-like reproductive and neuroendocrine phenotype".
Fortunately, a group of scientists managed not only to determine the cause of polycystic ovary syndrome, but also to reverse the development of the disease (although so far only in mice). To do this, animals with PCOS-like symptoms were injected with a drug commonly used in reproductive medicine, an antagonist of the gonadotropin-releasing hormone cetrorelix. Treatment led to the disappearance of the symptoms of the disease.
This is great news for millions of women suffering from manifestations of PCOS: excessive hair growth, hair loss, acne and overweight. In addition, polycystic ovary syndrome is the most common cause of infertility.
Now a team of scientists plans to test the effect of the drug on humans. It is expected that a study with the participation of volunteers will be conducted this year. Researchers hope that cetrorelix will help women restore normal ovulation frequency and even increase the likelihood of pregnancy.
Portal "Eternal youth" http://vechnayamolodost.ru