Singapore Bio Glue
The new CaproGlu surgical adhesive stitches vessels and tissues by itself
Stepan Ikaev, Hi-tech+
Nanyang Technological University has created an analgesic "bio-rubber" with many useful properties. A biocompatible material called CaproGlu is able to connect blood vessels, accelerate tissue healing, and can also become a platform for the delivery of painkillers.
To make the material, the team combined two ingredients – biodegradable polycaprolactone and the photosensitive molecule diazirine, which forms strong bonds when activated. The glue resolves itself a few weeks after application, and it is enough to apply a low dose of ultraviolet radiation to activate the material, according to a press release from NTU Singapore scientists develop “biorubber" glue for faster surgical recovery and pain relief.
Article by Djordjevic et al. CaproGlu: Multifunctional tissue adhesive platform is published in the journal Biomaterials – VM.
A team of scientists proved the effectiveness of CaproGlu during a series of animal tests prepared in collaboration with clinicians from Singapore General Hospital (SGH). According to the authors of the study, the new development will speed up surgical operations by 25%, since specialists will not waste precious time on stitching blood vessels and tissues. In addition, CaproGlu is suitable for the delivery of local anesthetics or painkillers to the tissues of the body and can be used in a humid environment, for example, in the human body, which also reduces the operation time.
"In order for our glue to work on wet fabrics, we have developed a material that removes water from the surface and thus provides adhesion to dehydrated surfaces," explains Associate Professor Terry W. J. Steele, one of the authors of the project.
The advantages of CaproGlu do not end there. Unlike existing bioadhesives, which require mixing two prepared chemicals, the new material offers a ready-made liquid gel solution in one container. Scientists compared the adhesion strength of CaproGlu with other materials presented on the commercial market, and found that their "bio-rubber" is 3-7 times more effective.
In addition to vital operations, scientists have shown that CaproGlu can be used for suturing. Instead of the usual eight stitches needed to connect the two ends of a blood vessel in a rabbit, they used four stitches and wrapped the ends of the vessels with a biodegradable mesh soaked in CaproGlu and cured with a small dose of UV light, which then stitched amino acids onto the surface of the tissue. Seven days later, the damaged artery on the animal's body completely healed.
Now scientists are considering the use of CaproGlu on bones and other organic surfaces, cooperating with leading hospitals in Singapore and planning to commercialize the new material.
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