Satellite cells will help with burns

Stem cells improve muscle regeneration in people with burns

VashaSpina.ru

Scientists have discovered a new way to regenerate muscles in people with severe burns that lead to deep atrophy of skeletal muscles.

The results of the study showed that patients with burns have a low level of satellite cells – stem cells that are responsible for maintaining and regenerating skeletal muscles after injury.

The researchers found that severe burns lead to the death of cells in the muscles, and also activate the regenerative properties of satellite cells.

"Our results highlight the therapeutic potential of satellite cells as a means to restore and preserve muscle mass in people with severe burn injury," said lead researcher Celeste C. Finnerty, associate professor of medicine at the University of Texas (in a press release The Physiological Society Stem cell therapy as a potential treatment for severe burns patients).

In addition, the researchers found that a large number of satellite cells in patients with burns express the protein Ki67 – a marker of cell proliferation

"We found a very large amount of the Ki67 protein, which indicates that the burn activates satellite cells and thus stimulates the regeneration of skeletal muscles," added lead author Christopher S. Fry, associate professor of medicine at the University of Texas.

The researchers analyzed tissue samples taken from 12 patients with severe burns and 12 healthy people.

They conducted an immunohistochemical study in order to analyze and compare the content of satellite cells, determine the level of cell activation and death, and evaluate the regeneration of muscle fibers in tissue samples.

Immunohistochemical examination is the process of detecting antigens in tissue cells.

"It is necessary to conduct additional research on treatment methods that can prevent the death of satellite cells, as well as promote their activation for the regeneration of skeletal cells, improving the recovery of patients with severe burns," Finnerty noted.

The study was published in The Journal of Physiology (Fry et al., Satellite cell activation and apoptosis in skeletal muscle from severely burned children – VM).

Portal "Eternal youth" http://vechnayamolodost.ru  07.07.2016