Breast cancer: another gene
A new oncogene of breast cancer has been discovered
The results of the work of researchers from the Case Western Reserve University School of Medicine, conducted under the supervision of Dr. Mark Jackson, are published in the Journal of Clinical Investigation.
"Using an objective screening method, we discovered the FAM83B oncogene. When this gene is overexpressed in breast cells, normal cells begin to behave like cancer cells," Jackson noted. In their work, the scientists used the technique of insertion mutagenesis. It allows you to achieve the appearance of the necessary mutations in genes by introducing DNA sections into the cell through capillaries or special pipettes, the diameter of the tips of which varies from 0.5 to 10 micrometers.
During the experiment, scientists found that the removal of FAM83B suppresses the proliferation of tumor cells. Analysis of tumor samples showed that the expression of this gene was significantly increased in cancer cells. It has also been proven that FAM83B is associated with the emergence of the most aggressive subtype of breast cancer, the so-called triple negative cancer. This subtype of tumor is characterized by an increased ability to form metastases and a low survival rate of patients.
The discovery of FAM83B, according to scientists, opens up new opportunities for the development of drugs against triple-negative breast cancer. "Our discovery provides the basis for the development of a new treatment that will inhibit FAM83B in aggressive cancers that are difficult to treat. Now we are trying to develop a drug that will suppress the function of this gene," Jackson said.
Breast cancer is one of the most common oncological diseases among women. Occasionally it occurs in men, who make up less than one percent of the total number of cases. The number of cases of this malignant tumor has increased dramatically in developed countries over the past 40 years.
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