Stroke risk test
Up to 40% of cases of ischemic stroke can be genetically caused
Irina Reznik, Mednovosti
Russian scientists have developed a set of reagents to determine the individual genetic risk of ischemic stroke. The test for determining the predisposition to stroke was tested in several scientific centers, based on the results obtained, an original method for calculating individual genetic risks was developed and a patent was obtained.
On October 29, the World Stroke Day was celebrated in many countries of the world, which the World Health Organization declared a global epidemic.
Stroke is an acute violation of cerebral circulation, causing the rapid development of focal and / or cerebral neurological symptoms. There are two main types of stroke – ischemic (cerebral infarction) and hemorrhagic (intracerebral hemorrhage). According to WHO, this disease claims more than 6.2 million human lives a year, and more than 50 million stroke survivors live with some form of disability.
More than half a million strokes are registered in Russia every year, and the mortality rate in our country is one of the highest in the world (127 for every 100 thousand people per year).
Stroke is a multifactorial disease. According to the WHO classification, risk factors include modifiable factors (unhealthy lifestyle and related diseases), a number of cardiovascular and endocrine diseases and unmodified factors (heredity, age, gender). At the same time, stroke is rapidly getting younger, affecting people 35-40 years old. Scientists are sure that "young strokes" are associated not only with an incorrect lifestyle – one of the main risk factors is a hereditary predisposition. According to various sources, up to 40% of cases of the disease can be genetically determined. Therefore, one of the tasks of stroke prevention today is to identify risk groups with a hereditary predisposition to the disease at the pre-symptomatic stage.
Over the past 10 years, serious research has been conducted around the world on the hereditary component of stroke, namely genetic factors that determine the risk of its development. Articles by German and American scientists on studies of the FOXF2 gene, mutations of which, according to the authors, can directly affect the risk of stroke, were published in 2016 in the journal Lancet Neurology. Previously, scientists have found that the likelihood of the disease is associated with genes whose products are involved in atherogenesis, and genes that affect the process of blood clotting.
"Stroke is a multifactorial disease associated with the functioning of various body systems initially determined by heredity," says Vitaly Korchagin, an employee of the scientific group for the development of new methods for detecting genetic polymorphisms of the Central Research Institute of Epidemiology of Rospotrebnadzor. "And the more tests we do, the greater the contribution of the genetic component to early stroke we see." If a person knows about his genetic predisposition to stroke, leads a healthy lifestyle, monitors health indicators and controls risk factors, then the likelihood of developing the disease decreases, says Korchagin.
Based on world research, researchers at the Central Research Institute of Epidemiology of Rospotrebnadzor have developed
a set of reagents that allows you to determine the individual genetic risk of ischemic stroke. The test was tested in several scientific centers, based on the results obtained, an original method for calculating individual genetic risks was developed and a patent was obtained. "Currently, the test for determining genetic predisposition to stroke is undergoing the registration procedure in Roszdravnadzor, we are confident that its introduction into clinical practice will make it possible to make a big step in the individualized prevention of ischemic stroke," Korchagin notes.
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