Target for gene therapy of alcoholism

Scientists have found a gene "button" to turn off cravings for alcohol

Svetlana Maslova, Hi-tech+

A gene that affects alcohol dependence in animals has been identified. It is likely to be an excellent target for the treatment and prevention of alcohol abuse in humans.

Researchers from Oregon State University of Science and Health (USA) has identified a gene called GPR39 (G-protein coupled receptor 39, G-protein coupled receptor 39 gene) – a likely new target for the development of drugs against alcohol addiction. The team conducted a series of experiments with animals and found out that exposure to the gene affects alcohol adherence, according to the university's website (Study identifies new target to prevent, treat alcoholism).

Observations of primates showed that the animals voluntarily consumed an increased amount of alcohol against the background of reduced gene expression in the brain. Further experiments with mice revealed the mechanism of interaction between alcohol and GPR39 activity.

By increasing the level of the protein associated with GPR39, the scientists reduced the alcohol consumption of the subjects by 50%.

This did not affect the amount of fluid consumed or the general state of health, the authors emphasize.

Now the team is studying brain tissue samples of people who died of alcoholism. The authors hope to see a similar relationship between them. Then exposure to GPR39 will become a target for the treatment of alcoholism and, possibly, mental disorders. Previously, this protein was associated with increased risks of depression in humans.

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