Nanobur for cell wall
Nanomaterials have been created to deliver drugs inside the cell
Anton Bugaichuk, Naked Science
Scientists at the University of Oregon have developed self-assembled peptide nanomaterials that facilitate the delivery of drugs through the cell membrane. They were abbreviated by the abbreviation CSPN (cell-penetrating self-assembling peptide nanomaterials).
A well–known problem of pharmacological therapy is that it is not enough to develop a drug, its molecules must be delivered "as intended". Moreover, we are not talking about organs or even their cells, but about penetration through such biological barriers as cell membranes. In order for the drug to work, it must get inside the cell and interact with the corresponding molecules. Previously, nanotechnology had already been used for drug delivery, even "barcodes" were invented for them, but the problem of biological barriers remained.
The head of the study, Gaurav Sahay, talks about the discovery:
"CSPNS represent a new modular drug delivery platform that can be programmed into desired structures by fine-tuning amino acids in a specific sequence."
The new technique makes it possible to assemble a "drill" from amino acids, which easily penetrates through the cell membrane. Together with it, medicinal substances can be delivered into the cell through a "drilled hole". It is possible to selectively configure such a "nano-device" for specific pharmacological needs. Scientists emphasize that it is possible to regulate not only the efficiency of penetration into the cell, but also parameters such as biodegradability and biocompatibility.
The possible forms of CSPN differ in the degree of torsion
© Ashvanikumar, University of Oregon
The researchers immediately tested the new structures in practice, testing the effectiveness of five different CSPNS. In all cases, the experiments were successful.
The twisting of the "nanobur" is adjusted by adjusting the ratio of the number of hydrophobic and hydrophilic molecules.
The discovery made in the future may become a new platform for delivering drug molecules directly through biological barriers that were previously considered practically impenetrable. The ability to "configure" and "target" is unique. This technology has every chance to play an integral role in the pharmaceutical industry of the future.
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