Aging and thrombosis
Cellular aging was associated with the formation of blood clots
Scientists from the Buck Institute for Aging Research have identified 44 proteins associated with cellular aging that are involved in blood clotting.
Researchers have found out for the first time that it is associated with the formation of blood clots over the course of age. An article about this was published in the journal Cell Reports (Wiley et al., SILAC Analysis Reveals Increased Secrecy of Hemostasis-Related Factors by Senescent Cells).
As they age, the cells begin to change irreversibly, and over time they become dangerous to the body. After their death, they release a cocktail of proteins, which, accumulating in the body, cause chronic inflammation, which can eventually lead to cancer. Therefore, the search for the causes of cell aging and ways to prevent or slow down this process is a very relevant area of research.
"The frequency of venous thrombosis, which includes deep vein thrombosis and pulmonary embolism, is extremely low until the age of 45, after which it begins to grow rapidly. Over time, this becomes a major factor in increasing the risk of death. By the age of 80, this disease affects from five to six people per thousand, – says the lead author of the study, Judith Campisi. – Blood clots are also a serious side effect of chemotherapy, which generates a huge number of aging cells in those undergoing treatment. That's why blood-thinning substances are often used in the treatment of such diseases."
Scientists from the Buck Institute for Aging Research and other laboratories around the world are working on the creation of senolytics – drugs that would cleanse the body of aging cells. They could potentially become part of the therapy of many age-related diseases that are either caused by or associated with aging. These include Alzheimer's and Parkinson's diseases, cardiovascular diseases, osteoarthritis, macular degeneration, age-related forms of cancer and sarcopenia.
In this study, scientists confirmed the expression of certain specific factors in cultured cells and in mice that were treated with doxorubicin, a widely used chemotherapeutic drug that induces cellular aging. The mice treated with the drug were found to have increased blood clotting, similar to what happens in people who undergo chemotherapy. Conversely, when scientists selectively removed aging cells from specially bred transgenic mice, the increased clotting caused by doxorubicin disappeared. The authors also found 343 proteins that are released during aging of human fibroblasts. 44 of them were associated with blood clotting.
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