Diabetes and antibiotics
Scientists: the use of antibiotics can accelerate the onset of diabetes
RIA News Analysis of the history of type 2 diabetes in 170 thousand Danes showed that many of them used unusually many antibiotics before they were diagnosed, which may indicate the role of such drugs in the development of insulin immunity, doctors say in an article published in the Journal of Clinical Endocrinology and Metabolism (Suzanne E. Fenton and Linda S. Birnbaum, Large scale discovery and validation studies demonstrate significant reductions in circulating levels of IL8, IL-1Ra, MCP-1 and MIP-1ß in type-1 diabetes patients).
According to official statistics, today about 3.7 million Russians suffer from diabetes mellitus. According to the estimates of the International Diabetes Federation, there are actually 12.7 million such people, since official statistics take into account only those patients who seek treatment. In the United States, the number of diabetics exceeds 29 million people.
Christian Mikkelsen from the University of Copenhagen (Denmark) and his colleagues have revealed one of the possible reasons for the rapid increase in the number of diabetics in developed and developing countries by analyzing the medical histories of over 170 thousand Danes who are carriers of type II diabetes today. In parallel, scientists have studied the biographies of over 1.3 million healthy residents of the kingdom.
Analyzing the medical histories of patients and biographies of healthy people, scientists tried to find those factors – bad habits, diet features, level of education, type of work and other details of their lives – that could influence the likelihood that they would become diabetics.
A comparison of their biographies revealed a curious fact – most diabetics took an unusually large number of antibiotics just before they developed diabetes. In some cases, the "fascination" with drugs continued for 15 years before the diagnosis, and on average diabetics used 1.5 times more antibiotics than healthy Danes.
Scientists believe that this unusual relationship may be explained by the fact that antibiotics have a negative effect on the intestinal microflora, which processes a significant part of sugar and glucose that enters our body with food. On the other hand, Mikkelsen and his colleagues are not yet ready to draw a line between antibiotics and diabetes, since this requires additional experiments and make sure that the drugs really interfere with the work of microbes, preventing them from metabolizing sugars.
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14.09.2015