A new way to fight aging
Anna Kerman, XX2 century
Aging is accompanied by the development of metabolic disorders and senility. Recent studies have demonstrated that a decrease in the level of nicotinamide adenine dinucleotide (NAD+) – a key factor in slowing down metabolic processes associated with age. Are there ways to influence the concentrations of NAD+ in the body in such a way as to slow down aging?
The authors of the new study have previously demonstrated that the age-related decrease in NAD+ levels is closely related to the work of the CD38 enzyme. Within the framework of the new work, the same team of authors showed that the potent specific thiazolokvinazolinone inhibitor CD38, 78c, reverses the process of reducing the concentration of NAD+.
Article by Tarragó et al. A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline is published in the journal Cell Metabolism.
It is important that the experimental mice that received 78c improved many indicators that deteriorate as the body ages. Thus, scientists have registered normalization of glucose tolerance, improvement of muscle and cardiac functions, as well as increased exercise tolerance.
The introduction of a CD38 inhibitor into the body of experimental animals led to an increase in the concentration of NAD+, and it, in turn, affected factors related to health and longevity: sirtuins, AMP-dependent kinase and poly(ADP-ribose)- polymerase. Moreover, in animals treated with 78c, inhibition of signaling pathways negatively affecting life expectancy was observed, in particular, the activity of mTOR-S6K and ERK was suppressed. There was also a decrease in telomere-related DNA damage in mice.
The results of the new work indicate the possibility of creating a new pharmacological strategy to prevent or reverse the age-related decline in the level of NAD+ and related metabolic disorders.
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