I am a little mouse, and I want to live a long time!

Life and health are truly priceless. Therefore, many researchers around the world are working on methods to increase life expectancy and, in particular, to increase the number of so-called "healthy years of life".

The efforts of scientists lead to the emergence of an increasing number of compounds that can potentially prolong life and delay the development of age-related diseases. However, conducting clinical trials to confirm their effectiveness takes decades. Moreover, before conducting clinical trials, animal studies are necessary, which also require large financial and time costs.

Specialists of the Kiev Institute of Gerontology, working under the guidance of Professor Irina Pishel, offer everyone to support the search for eternal youth by donating to the project "I am a little mouse, and I want to live a long time" launched by their laboratory! The essence of the project is to test the ability of a combination of drugs to increase the lifespan of mice.

To date, the laboratory has a fairly large number of aging mice, whose age is about 20 months (usually the lifespan of mice is 2-3 years) of the C57Bl6 line. They plan to divide the animals into 2 experimental groups (females and males) and 2 control groups. Each group will include 24 animals. The experiment will be conducted by the blind method.

The diet of animals will contain the following drugs:

• alpha-adrenergic receptor blocker metoprolol. Potential effect: preventing the development of too high heart rate;
• an inhibitor of the mTOR-mediated signaling mechanism everolimus, whose action is similar to that of rapamycin. Potential effect: puts cells into an active stable mode of functioning;
• metformin. Potential effect: normalizes the levels of insulin-like growth factor-1 in the blood at low values. It can potentially have effects similar to the effects of Everolimus;
• simvastatin. Effect : reduces the content of low-density lipoproteins (the so-called "bad" cholesterol) in the blood;
• ramipril is an angiotensin-converting enzyme inhibitor. Effect : prevents the development of hypertension;
• aspirin. It is believed that taking small doses of aspirin has minor side effects on the background of improving blood flow and, accordingly, reducing the risk of developing diseases of the cardiovascular system, and also potentially has the ability to reduce the likelihood of developing certain types of cancer.

The collected funds will be spent on the purchase of drugs and animal feed, as well as on maintaining the conditions of keeping animals necessary for the experiment.

The authors also note that all donations collected in excess of the initially stated amount will be spent on testing the effectiveness of other drug combinations.

The details of the project can be found on the website Indiegogo.com . However, you should hurry up, as there are only 5 days left before the end of the fundraising.

Evgeniya Ryabtseva
Portal "Eternal youth" http://vechnayamolodost.ru based on Indiegogo materials:
I am a little mouse and I want to live longer!

16.10.2013