17 April 2018

Bacteriophages "all in one"

Rostec has developed the world's first universal bacteriophage to fight infections

Rostec

The Scientific and Production Association "Microgen" of the National Immunobiological Company ("Natsibio") has developed a universal drug that allows one capsule to replace the reception of a complex of traditional antimicrobial agents for infectious diseases. The drug affects only bacterial cells, without affecting the microflora necessary for the body.

The drug is an oral capsule containing a specialized complex of bacteriophages in dry form that resists diseases caused by several pathogens at the same time. This eliminates the need to take a complex of medications for the treatment and prevention of each disease separately.

The effect of the drug, unlike traditional antimicrobial agents, including antibiotics, is based on the targeted destruction of exclusively harmful pathogen cells. Bacteriophages do not affect the microflora "useful" for the body and do not have a side effect, which excludes the possibility of dysbiosis and the appearance of complications in the work of vital organs: liver, kidneys, intestines. After the destruction of pathogenic bacteria, the drug is completely eliminated from the body naturally.

"There is no similar development anywhere in the world – one capsule included an antimicrobial complex of bacteriophages for the prevention and control of a number of common bacteria. The drug has already been created and will enter the market after passing the necessary research and state registration. At the moment, preclinical and the first phase of clinical trials have been successfully completed, which have shown its safety," said Kirill Gaidash, Director General of the NGO Microgen.

The development of Rostec will allow the treatment and prevention of diseases caused by bacteria of the genus Staphylococcus (Lat. Staphylococcus), Streptococcus (Streptococcus), proteus (Proteus – P. vulgaris, P. mirabilis), Klebsiella (Klebsiella pneumoniae), as well as Pseudomonas aeruginosa and E. coli (Escherichia coli).

These bacteria are the cause of a number of ENT diseases (angina, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy), surgical and urogenital infections (abscess, hydroadenitis, paraproctitis, mastitis, osteomyelitis, cystitis, pyelonephritis, endometritis and others), various kinds of generalized septic and purulent–inflammatory diseases of newborns.

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