Diagnosis of leukemia from MEPHI

MEPhI scientists have proposed a solution for the classification of blast cells in the diagnosis of acute lymphoblastic leukemia

MEPhI Press Center

Currently, the diagnosis of acute leukemia is based on manual counting of different types of cells from blood smears and bone marrow aspirates. The data of the morphological examination carried out by a doctor with microscopic analysis of blood and bone marrow preparations indicate a significant variability of blast cells, and as a consequence, leading to difficulties in identifying cell types and possible errors in diagnosis. In acute lymphoblastic leukemia, the presence of leukemic cells morphologically similar to lymphoblasts in the blood or bone marrow requires differential diagnosis with other lymphoproliferative diseases and with reactive lymphocytosis. In some cases, this presents a difficult diagnostic problem.

The use of computer microscopy to classify bone marrow and blood cells makes it possible to clarify the characteristics of lymphocytes and leukemic blasts. Specialists of the Department No. 46 "Computer Medical Systems" of MEPhI together with colleagues from the Laboratory of Hematopoiesis Immunology of the Russian Cancer Research Center named after N.N. Blokhin of the Ministry of Health of the Russian Federation investigated and showed the applicability of methods of textural analysis of images of chromatin nuclei for separation into blasts and lymphocytes for the diagnosis of acute lymphoblastic leukemia.

During the research, the results of the work for which the RF patent No. 159002 was obtained earlier (2015) were used.

The results of the work can be used to obtain additional independent objective criteria for the diagnosis of acute lymphoblastic leukemia.

According to the postgraduate student of the Department No. 46 E.V. Polyakov, in order to improve the accuracy of the diagnosis of hematological diseases, the planned stage of further research is the differentiation of blasts from other types of blood cells found in peripheral blood and bone marrow normally.

Portal "Eternal youth" http://vechnayamolodost.ru  16.09.2016