The "peydodna" gene

A gene that prevents fruit flies from getting drunk has been foundIvan Panin, Infox.ru
A gene has been discovered, changes in which help the body withstand the effects of alcohol.

The studies were conducted on fruit flies – fruit flies, but they are also relevant for humans.

Scientists from the University of North Carolina conducted a study on fruit flies (Drosophila melanogaster), in which the reaction time to alcohol was measured. At the same time, the essence of the work was to collect data on the work of the entire fly genome. The activity of various genes under the influence of alcohol was studied.

It turned out that single changes in the gene responsible for the enzyme Malic Enzyme 1 (the so-called "apple enzyme", NADH–dependent malate dehydrogenase - VM) can affect the body's reaction to alcohol. This enzyme accelerates the reaction of malic acid formation from pyruvic acid, and also affects other processes.

In total, the researchers found in the DNA sequence of flies seven different added single pairs of nucleotides that can increase the ability to withstand the effects of alcohol.

Researchers report that the gene responsible for ME 1 also exists in humans. And with certain changes in the gene, there is a tendency to stronger alcoholic beverages.

"Our results indicate metabolic features associated with alcohol addiction, which can ultimately lead to alcoholism," said study leader Robert Enholt.

"Research like ours helps to get to the bottom of human biology, to find a balance between natural factors and the influence of education on our actions," added Anholt.

The results of the study were included in the October issue of the journal Genetics.

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23.10.2009