Two more anti-aging products
As reported by ChemPort.Ru researchers from Austria have shown that feeding worms, fruit flies and yeast cultures with a simple linear polyamine spermidine (spermidine) can significantly extend their life time. In addition, the introduction of spermidine into the diet of mice reduces the concentration of molecular markers of aging. The cultivation of human immunocytes in a spermidine-containing medium also makes it possible to prolong their life.
Spermidine, which is contained in large quantities in human sperm and grapefruit, is necessary for the growth and maturation of cells, with the aging of cells, the content of spermidine in them decreases. Frank Madeo from the University of Graz showed that simple additives of spermidine in the food of some organisms and cells can significantly increase their life time (Induction of autophagy by spermidine promotes longevity, Nature Cell Biol., 2009, DOI; 10.1038/ncb1975).
Yeast cells cultured in a medium rich in spermidine had a lifespan three to four times longer than that of the control group of cells that did not receive forced feeding with spermidine, the lifetime of human immunocytes also tripled. The transition to the study of organisms also led to positive results – the life expectancy of fruit flies and microscopic nematodes, in whose diet spermidine was added, increased by 30%.
Perhaps spermidine affects the mechanism by which the cell processes damaged internal components. Throughout the life of a cell, proteins and other biological molecules are damaged by external factors, such as ultraviolet light and oxidants. Fragments of such molecules are collected in a biochemical "trash can". As we age, the cell's self-cleaning process, autophagy, becomes less efficient, and the accumulation of waste leads to cell death. Researchers believe that spermidine inhibits the production of a protein that inhibits the activation of genes responsible for the autophagy process.
Portal "Eternal youth" http://vechnayamolodost.ru07.10.2009