Booster for cancer vaccines
Found a way to prevent cancer in the bud
Svetlana Maslova, Hi-tech+
Scientists have discovered a molecule that protects against many types of cancer at once, and even before the formation of tumors. And if the disease is detected, it enhances the effect of immunotherapy.
Researchers from The University of Louisville (USA) has proved that the SA-4-1BBL molecule is able to enhance the therapeutic activity of cancer vaccines. Preclinical animal studies have proven the method's promise for many types of cancer, according to the university's website (Immune stimulant molecule shown to prevent cancer).
Article by Barsoumian et al. A Novel Form of 4-1BBL Prevents Cancer Development via Nonspecific Activation of CD4+ T and Natural Killer Cells is published in the journal Cancer Research – VM.
The SA-4-1BBL molecule increases the effectiveness of CD8 + T cells of the immune system, which are pre-trained to attack the tumor, the authors explain.
"The molecule can form an immune response of the body even with rare malignant cells and is able to prevent cancer before it is fixed in the body," says scientist Haval Shirvan.
The therapy works even when the tumor in the body has not yet formed, Shirvan emphasizes. This is a serious achievement, because usually the immune system "turns on" anti-cancer activity only in response to the detection of a tumor.
In experiments with mice, the team applied SA-4-1BBL to healthy rodents, and then exposed them to malignant cells from lung and cervical tumors. The mice showed significant protection against tumor development with a maximum level two weeks after therapy. The overall effect of cancer immunoprophylaxis lasted for eight weeks.
The authors claim that the protective function of SA-4-1BBL works against all types of tumors, which means that it will increase the effectiveness of immunotherapy for all oncological diseases that are treated with this method.
The team hopes to test the approach in clinical trials on people at risk of cancer and among patients with precancerous lesions.
Perhaps the method will be effective for osteosarcoma. For this type of cancer, scientists from another American university have developed an immunotherapy method that replaces chemotherapy.
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