12 January 2012

Prostate cancer, get drunk on poison!

Nanocytes will feed tumor cells with poison

ABC Magazine

For the first time, a group of American researchers managed to create an accurate system for delivering a chemotherapeutic drug precisely to prostate cancer cells. The results of their study are published in the journal ACS Nano (Engineering of Targeted Nanoparticles for Cancer Therapy Using Internalizing Aptamers Isolated by Cell-Uptake Selection).

The study, led by Dr. Omid Farokhzad, involved scientists from the Department of Anesthesiology at Brigham and Women's Hospital (BWH), the Massachusetts Institute of Technology (Massachusetts Institute of Technology, MIT) and the Massachusetts General Hospital (Massachusetts General Hospital). The technology of drug delivery to the cell is as follows: scientists isolated specific ligands (molecules that can bind to the surface of certain cells) for prostate cancer cells, and then supplied them with nanoparticles of the chemotherapy drug docetaxel.


Diagram from the article in ACS Nano – VM

The specific ligands created by scientists are not only able to distinguish between tumor and non-tumor prostate cells with absolute accuracy. They were specially designed to be "swallowed" by tumor cells. Thus, the chemotherapy drug achieves its goal and kills the cancer cell, which significantly reduces the necessary dosage of the drug and its side effects.

Currently, scientists continue to investigate the effectiveness of the technology they have developed in the treatment of cancer of other organs.

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12.01.2012

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