Superthrombocytes
A group from the University of British Columbia led by Christian Kastrup has developed a protocol for enhancing the properties of platelets.
Coagulation depends on a number of complex biochemical transformations. The mechanism is perfectly debugged and works fine with minor injuries like abrasions. But trauma with extensive bleeding often disrupts it, thrombosis slows down.
Platelets are the first to react to ruptures of blood vessels. They accumulate in the area of damage, their shape changes from smooth and round to stellate, so they can easily stick together.
But this is only part of the coagulation. To close the wound, platelets must create a spongy mass that hardens and forms a blood clot. This is possible only with the participation of the fibrin protein, which is formed as a result of a cascade of reactions involving the enzyme thrombin.
In a stressful situation, for example, due to injury, coagulopathy occurs – the process of fibrin formation is disrupted.
The researchers decided to modify the platelets so that they work effectively with massive bleeding. To do this, they placed thrombin molecules in small natural bubbles-containers – liposomes, and added them to the platelet mass. After the liposomes were embedded in platelets, they were injected into different types of blood samples.
Thrombin in "super platelets" accelerated the clotting process of blood taken from healthy people by an average of 30% compared to conventional platelets. The resulting blood clots were 20% denser.
In blood samples taken from two patients with traumatic coagulopathy, the clotting process with the participation of modified platelets was 20-40% faster.
Modified platelets also accelerated clotting time in the case of increased blood acidity, characteristic of extensive injuries, or against the background of long-term administration of acetylsalicylic acid preparations. In addition, they have shown their effectiveness in hemophilia, a hereditary disorder of blood clotting.
If superthrombocytes perform well in experiments on animal models and in clinical studies that have yet to be conducted, then they can be equipped with traumatology departments.
Acute blood loss is the second most common cause of injury-related death under the age of 45. A new tool that allows you to strengthen the body's own forces to combat bleeding will help significantly increase survival.
Article V. Chan et al. Platelets loaded with thrombin‐encapsulated liposomes have increased coagulability published in the Journal of Thrombosis and Haemostasis.
Aminat Adzhieva, portal "Eternal Youth" http://vechnayamolodost.ru based on the materials of the University of British Columbia: Look! Down in the petri dish! It’s a Superplatelet!