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Breakthrough drug suppresses inflammation in the brain and spinal cord
Svetlana Maslova, Hi-tech+
The therapy developed by American scientists opens up opportunities for the treatment of a large number of neurological diseases, including both acute and chronic conditions, such as spinal cord injuries, Alzheimer's and Parkinson's disease, and many others.
Experimental therapy was presented by scientists from University of Alabama at Birmingham. They developed a low-molecular-weight drug SRI-42127 and successfully tested it in preclinical studies.
Article by Chellappan et al. SRI-42127, a novel small molecule inhibitor of the RNA regulator HuR, potentially attenuates glial activation in a model of lipopolysaccharide-induced neuroinflammation published in the journal Glia – VM.
Testing of therapy on animal models and human cells showed that SRI-42127 effectively suppressed inflammation triggers and passed through the blood-brain barrier of the brain. The treatment acted on cytokines and chemokines secreted by microglia and astroglia cells in the brain and spinal cord in response to the activation of the inflammatory process, the scientists explain.
The development of breakthrough therapy was preceded by 25 years of collaboration between scientists Peter King and Bert Nabors, who studied all potential mechanisms that trigger or participate in neuroinflammation. It is known that neuroinflammation can worsen the prognosis of stroke, traumatic brain injury and spinal cord injury, as well as provoke and accelerate the development of neurodegenerative diseases, including amyotrophic lateral sclerosis, Parkinson's disease and Alzheimer's disease.
This suggests that limiting neuroinflammation is a promising approach to the treatment of neurological diseases in acute or chronic form, as well as neuropathic pain. In the latter case, the new therapy may become an effective alternative to opioids.
The team is currently preparing the next stage of testing SRI-42127 on acute and chronic injury models.
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