Against gonarthrosis

A group of Canadian scientists led by Dr. Sowmya Viswanathan from the Krembil Research Institute conducted a clinical study of the effect of table cells of the patient's bone marrow on knee cartilage in osteoarthritis.

Osteoarthritis of the knee joint, or gonarthrosis, is a common disease of the aging population, in which cartilage wears out, resulting in bone damage, which ultimately causes severe pain. In the last stages of the disease, it is recommended to replace the joint.

In Canada's first clinical trial of gonarthrosis treatment methods, mesenchymal stromal cells (MSCs) obtained from the patient's bone marrow under local anesthesia were used.

The study involved 12 patients aged 45 to 65 years with moderate and severe gonarthrosis. They were divided into three groups, each of which received a different dose of MSCs. Each patient was injected with his own cells. The scientists then followed the patients for the next 12 months using analytical methods such as imaging, biomarkers, molecular certification and their own assessment of the patient's condition.

At the end of the year, the researchers noted a significant reduction in pain and an improvement in the quality of life of patients. The study also showed that MSCs were safe in all tested doses and the effectiveness of this treatment method increased with increasing doses. It was noted that the heterogeneity of donors is an important factor, and the collected genetic panel helps to identify cells that are effective in osteoarthritis.

Article by Chahal et al. Bone Marrow Mesenchymal Stromal Cells in Patients with Osteoarthritis Results in Overall Improvement in Pain and Symptoms and Reduces Synovial Inflammation published in the journal Stem Cells Translational Medicine.

Elena Panasyuk, portal "Eternal youth" http://vechnayamolodost.ru /