Precision bone bioprinting
Researchers from the Tandon School of Engineering at New York University and the New York Stem Cell Foundation Research Institute have created an exact replica of the bone using a system combining biothermal imaging with a heated "nanodolot". In a study published in the journal Advanced Functional Materials, they describe in detail a system that allows them to build a biocompatible material with a detail smaller than the size of a protein. Lithography with biothermal scanning (thermal scanning probe lithography, bio-tSPL) takes a picture of bone tissue, and then uses it to create an exact copy of it.
A group led by Eliza Riedo, professor of chemical and biomolecular engineering at New York University Tandon, demonstrated that it is possible to scale up bio-tSPL to create copies of bones with the parameters necessary for biomedical research. Artificial bones are able to support the growth of living cells derived from the patient's own stem cells, creating the possibility of using stem cells for research and therapeutic purposes. This technology can significantly advance the creation of new drugs and lead to the development of more advanced orthopedic implants and devices.
In the human body, cells exist in certain environments that control their behavior and support tissue regeneration by transmitting morphological and chemical signals at the molecular level. In particular, bone stem cells are embedded in a matrix of collagen, bone proteins and minerals. The hierarchical structure of bone includes micro- and nanostructures, the complexity of which has so far prevented their reproduction by standard manufacturing methods.
TSPL is a powerful method of nanoproduction, which was first used several years ago.
The short production time, cost-effectiveness, as well as compatibility with stem cells and the possibility of reuse of bone copies make bio-tSPL an affordable platform for creating artificial tissues that perfectly reproduce any biological tissue with unprecedented accuracy.
The artificial bone tissue reproduced in this study demonstrates unique properties, opening up opportunities for understanding cell biology and modeling bone diseases, as well as for developing more advanced drug screening platforms. Bio-tSPL will also be useful in creating more effective orthopedic implants for the treatment of skeletal and maxillofacial defects resulting from injury or disease.
Article X.Liu et al. Cost and Time Effective Lithography of Reusable Millimeter Size Bone Tissue Replicas With Sub-15 nm Feature Size on A Biocompatible Polymer is published in the journal Advanced Functional Materials.
Aminat Adzhieva, portal "Eternal Youth" http://vechnayamolodost.ru based on NYU Tandon: Researchers use hot nano-chisel to create artificial bones in a Petri dish.