Chlamydia? Mycoplasmosis? Try gene therapy!
Gene therapy will help to cope with mycoplasmas and chlamydiaAnastasia Kazantseva, STRF.ru
Antimicrobial peptides isolated from arthropod poisons are promising competitors to conventional antibiotics.
However, their introduction into the body is associated with a number of difficulties (for example, they can decay there ahead of time, they are expensive to synthesize, they can cause allergies). Therefore, Russian scientists have developed a new approach: genes encoding antimicrobial peptides are introduced into animal cells. When faced with an infection, these genes can be activated, and the cells themselves will begin to produce the drug. Vasily Lazarev, head of the Laboratory of Genetic Engineering of the Research Institute of Physico-Chemical Medicine, told more about the method at the conference "Postgenomic methods of analysis in biology, laboratory and clinical Medicine", held in Moscow on November 17-19, Informnauka reports.
Antimicrobial peptides are a component of the innate immunity systems of animals, plants and fungi. These substances bind to the membranes of bacteria and damage them. Scientists have long considered antimicrobial peptides as an alternative to antibiotics, but their use is associated with a number of difficulties, first of all, we are talking about the delivery of the active substance to the area of inflammation. Like all foreign substances of a protein nature, antimicrobial peptides are destroyed in the animal's body, and it is difficult to achieve their effective concentration in those areas where bacteria multiply.
The staff of the Research Institute of FCM and the Institute of Bioorganic Chemistry proposed to introduce into the body not the antimicrobial peptides themselves, but the genes in which their amino acid sequences are encoded. This approach has already shown good results in animals.
Scientists have worked with mycoplasma and chlamydia. These two kinds of bacteria are able to parasitize inside the cells of higher organisms, which makes treatment very difficult. But they are well susceptible to antimicrobial peptides, in this case – to mellitin from bee venom and latarcins from spider venom. Researchers have created a genetic vector containing an antimicrobial peptide gene and a system to regulate its production: the peptide is synthesized in cells not constantly, but only when the antibiotic doxycycline is added (this antibiotic itself does not act on chlamydia and mycoplasma).
After the system was tested on cell culture, the researchers began testing the method on animals. They worked with one type of chlamydia and two types of mycoplasma. The causative agent of avian mycoplasmosis (Mycoplasma gallisepticum) infected chickens. Two human parasites were tested on mice, for which it was necessary to artificially transfer bacteria from one mouse to another until natural selection led to the emergence of strains capable of effectively infecting an atypical host.
It turned out that timely activation of the production of antimicrobial peptides in animal cells leads to a complete cure of two thirds of them and to a significant reduction in the infectious load in the remaining third.
Vasily Lazarev does not exclude that in the future this technique can be used for the treatment of chlamydia and mycoplasmosis in humans, but emphasizes that the most important area of application of the new approach is agriculture. Mycoplasma gallisepticum causes epidemics of severe respiratory disease in birds and causes huge economic damage to poultry farming. Today, when the disease is detected, all birds on the farm are destroyed so that the disease does not spread to other farms. The introduction of a new technology will allow you to simply spray a suspension of genetic vectors in chicken coops. They will penetrate into the cells of the pulmonary epithelium of birds, and the disease will cease to be a serious threat: when it is detected in the first bird, the rest will simply add an antibiotic activator to the feed, antimicrobial peptides will begin to be synthesized in their cells, and the disease will be defeated.
Appendix: Conference programNovember 17th
9.30 – 10.00
discoveryLarge Biological Audience (BBA)
PLENARY REPORTS (Large Biological Audience (BBA)
10.00-10.40
"Obtaining the structure of genomes. What's after?"Scriabin K.G., Bioengineering Center of the Russian Academy of Sciences, RSC "Kurchatov Institute"
10.40-11.20
"Nano Bio Cogno – a new platform of science"Kovalchuk M.V., A.V. Shubnikov Institute of Crystallography of the Russian Academy of Sciences, RSC "Kurchatov Institute"
11.20-12.00
"Peptidomics – a plantation for the search for biomarkers"Ivanov V.T., Institute of Bioorganic Chemistry named after
Academicians M.M. Shemyakin and Yu.A. Ovchinnikov of the Russian Academy of Sciences
Break 12.00 – 12.1012.10-12.50
"Therapeutic preparations based on nucleic acids" Vlasov V.V., Institute of Chemical Biology and Fundamental Medicine SB RAS
12.50-13.30
"From the Human Genome project to the Human Proteome ProjectArchakov A.I., V.N. Orekhovich Research Institute of Biomedical Chemistry of the Russian Academy of Medical Sciences
breakBREAKOUT SESSIONS
(Audience – "M-1")
SECTION 1. GENOME AND TRANSCRIPTOME – NEW TOOLS FOR CANDIDATE GENE SEARCH AND DIAGNOSTICSModerators:
Polyakov A.V., Medical and Genetic Research Center of the Russian Academy of Medical Sciences
Prokhorchuk E.B., Bioengineering Center of the Russian Academy of Sciences, RSC "Kurchatov Institute"
Rogaev E.I., Institute of General Genetics of the Russian Academy of Sciences14.30 – 15.00
"Identification of genomic loci associated with predisposition to kidney cancer"Prokhorchuk E.B. (RSC "Kurchatov Institute", Bioengineering Center of the Russian Academy of Sciences, Moscow, Russia)
15.00 – 15.30
"Development of new therapeutic approaches to the treatment of genetic diseases on the example of polycystic kidney disease, identification of biomishens and modeling of disease mechanisms in vitro and in vivo"Bloodless O. ("Genzyme", USA)
15.30 – 16.00
"Selective decoding of nucleotide sequences and detection of structural changes in the genome using a second-generation sequencer "SOLiD" Guryev V. (University Medical Center, Utrecht, the Netherlands)
16.00 – 16.30
"Genome-wide analysis of the epigenetic status of human pluripotent cells"Lagarkova M.A., Kiselev S.L. (RSC "Kurchatov Institute", Moscow, Russia)
Break 16.30 – 16.4516.45 – 17.15
"Modern methods of detecting numerical aberrations of the human karyotype"Polyakov A.V. (Medical and Genetic Center of the Russian Academy of Medical Sciences, Moscow, Russia)
17.15 – 17.45
"RNA-Seq: transcriptome analysis using a second-generation sequencer (Illumina)"Soldatov A. (Max Planck IMG, Berlin, Germany)
17.45 – 18.15
"RNA interference as a new method of diagnostic determination of genes essential for the realization of various cellular functions"Filatov M.V., Shtam T.A., Varfolomeeva E.Yu. (PIAF RAS, Gatchina, Russia)
18.15 – 18.45
"Genome-wide analysis of gene expression in the study of glioma biology"Ivliev A.E., Sergeeva M.G. (Research Institute of the Moscow State University, Moscow, Russia)
18.45 – 19.05
"Pathogenomics: detection of disease genes by deep sequencing"Rogaev E.I. (IOGen RAS, Moscow, Russia)
(Large Biological Audience (BBA)
SECTION 4. GENOMICS AND PROTEOMICS OF MICROORGANISMSModerators:
Gelfand M.S., Institute of Information Transmission Problems of the Russian Academy of Sciences
Govorun V.M., Research Institute of Physico-Chemical Medicine of the FMBA of Russia, RSC "Kurchatov Institute", Institute of Bioorganic Chemistry named after Academicians M.M. Shemyakin and Yu.A. Ovchinnikov of the Russian Academy of Sciences14.30 – 15.00
"Co-evolution of transcription factors and their binding sites in DNA"Gelfand M.S. (IPPI RAS, Moscow, Russia)
15.00 – 15.30
"Dynamics, function and evolution of CRISPR systems in E. Coli"Severinov K.V. (IMG RAS, Moscow, Russia)
15.30 – 16.00
"Repeats in bacterial genomes and in life"Smirnov G.B. (NIIEM RAMS, Moscow, Russia)
16.00 – 16.30
"Assembling and annotation of the bacterial genome sequence exclusively from Roche 454 data. Challenges and opportunities"Makeev V.Yu. (IOGen RAS, Moscow, Russia)
16.30 – 17.00
"Comparative genomics of XDR strains of M.tuberculosis2"Ilyina E.N. (Research Institute of FHM FMBA of Russia, Moscow, Russia)
Break 17.00 – 17.1517.15 – 17.35
"Decoding the genomes of thermophilic archaea: fundamental and applied aspects"Ravin N.V. (Bioengineering Center of the Russian Academy of Sciences, Moscow, Russia)
17.35 – 17.55
"Proteogenomic typing of mycoplasmas"Alekseev D.G.
(MIPT, Research Institute of FHM FMBA of Russia, Moscow)
17.55 – 18.15
"Functional diversity of H.pylori in gastric adenocarcinoma"Momynaliev K.T. (Research Institute of FHM FMBA of Russia, Moscow, Russia)
18.15 – 18.35
"Acylation of mycoplasma proteins"Serebryakova M.V. (Research Institute of FHM FMBA of Russia, Moscow, Russia)
18.35 – 18.55
"From an open reading frame to experimentally confirmed information about function, structure and regulation: the experience of studying RNA-methyltransferases"Sergiev P.V. (Research Institute of the Moscow State University, Moscow, Russia)
18.55 – 19.15
"Evolution of pangenomes"Gordienko E.N. (IOGen RAS, Moscow, Russia)
19.15 – 19.35
"GntR family transcription factors: Evolution of regulatory systems"Suvorova I. (IPPI RAS, Moscow, Russia)
(Department of Biochemistry)
SECTION 5. POSTGENOMIC TECHNOLOGIES IN THE CREATION AND VALIDATION OF MEDICINAL COMPOUNDSModerators:
Efremov R.G., Institute of Bioorganic Chemistry named after Academicians M.M. Shemyakin and Yu.A. Ovchinnikov of the Russian Academy of Sciences
Poroikov V.V., V.N. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences
Shaitan K.V., Faculty of Biology, Lomonosov Moscow State UniversityChairmen: Shaitan K.V., Poroikov V.V.
14.30 – 14.50
"Computer design of new medicines"Zefirov N.S., Palyulin V.A. (Moscow State University, Moscow, Russia)
14.50 – 15.10
"From ribosome structure to the design of new antibiotics"Bogdanov A.A., Sumbatyan N.V., Shishkina A.V., Golovin A.V., Korshunova G.A. (Moscow State University, Moscow, Russia)
15.10 – 15.30
"The mechanism of degradation of autoantigens"Gabibov A.G. (IBH RAS, Moscow, Russia)
Break 15.30 – 15.45Chairmen: D.A. Dolgikh, V.A. Palyulin
15.45 – 16.05
"Molecular mechanisms of overcoming drug resistance"Severin E.S., Posypanova G.A., Kondrasheva I.G., Gukasova N.V., Moskaleva E.Yu. (VCMDL, Moscow State University, Moscow, Russia)
16.05 – 16.25
"Contribution of NMR spectroscopy to the creation of new medicinal compounds"Arsenyev A.S., Bocharov E.V., Shenkarev Z.O., Lyukmanova E.N., Chupin V.V., Petrovskaya L.E., Kirpichnikov M.P. (IBH RAS, Moscow, Russia)
16.25 – 16.45
"Fluorescent proteins in the creation of medicines: current state and prospects"Mishina N.M., Belousov V.V. (IBH RAS, Moscow, Russia)
16.45 – 17.05
"Cellular systems for the search and study of compounds acting on membrane receptors: new approaches and opportunities"Feofanov A.V., Nekrasova O.V., Sharonov G.V., Arsenyev A.S., Kirpichnikov M.P. (IBH RAS, Moscow State University, Moscow, Russia)
17.05 – 17.25
"Study of the interaction of human potential-dependent ion channel proteins with blockers promising for the creation of targeted pharmacological drugs"Sokolova O.S., Karlova M.G., Pishchalnikova A.V., Brazhe N.A., Kazakova T.A., Novoseletsky V.N., Maksimov G.V., Shaitan K.V. (Moscow State University, Moscow, Russia)
(Auditorium # 557)
SECTION 9. CELLULAR TECHNOLOGIES AND REGENERATIVE MEDICINEModerators:
Vasiliev A.V., N.K. Koltsov Institute of Developmental Biology of the Russian Academy of Sciences
Parfenova E.V., Research Institute of Experimental Cardiology of the Russian Cardiological Research and Production Complex of the Ministry of Health and Social Development
Chehonin V.P., Srpsky State Center for Social and Forensic Psychiatry14.30 – 15.00
"Cellular technologies in the correction of human reproductive functions"Sukhoi G.T. (NC AGiP RAMS, Moscow, Russia)
15.00 – 15.30
"Creation of a technological platform for cellular and tissue technologies as a basis for the development of a new field of biomedicine"Vasiliev A.V. (IBR RAS, Moscow, Russia)
15.30 – 16.00
"Genetically modified progenitor cells: the potential for improving the effectiveness of gene and cell therapy"Parfenova E.V. (RKNPC of the Ministry of Health and Social Development, Moscow, Russia)
16.00 – 16.30
"Implantation of neural stem cells in the correction of CNS functions in rats with experimental ischemic stroke"Volkov A.I. (SSP of the Ministry of Health and Social Development, Moscow, Russia)
16.30 – 17.00
"Fundamental approaches to the therapy of neurodegenerative diseases"Alexandrova M.A. (IBR RAS, Moscow, Russia)
Break 17.00 – 17.1517.15 – 17.35
"Transplantation of autologous regulatory T cells CD4+, CD25+, FoxP3+ in the correction of immunosuppression in autoimmune diseases and GVHD"Bykovskaya S.N. (RSMU of the Ministry of Health and Social Development, Moscow, Russia)
17.35 – 17.55
"Cord blood cells: yesterday, today, tomorrow"Romanov Yu.A. (RKNPC of the Ministry of Health and Social Development, Moscow, Russia)
17.55 – 18.15
"C-kit-positive human heart cells: characterization, cultivation and differentiation potential"Rubina K.A. (Moscow State University, Moscow, Russia)
18.15 – 18.35
"Prospects for the use of cellular technologies in medicine"Ivanov A.A. (Research Institute of Molecular Medicine MMA, Moscow, Russia)
18.35 – 18.55
"Intracerebral and subcutaneous implantation of neural stem cells in the treatment of experimental perinatal CNS injuries"Karasev A.V. (SSP of the Ministry of Health and Social Development, Moscow, Russia)
18.55 – 19.15
"Induced pluripotent stem cells suitable for cell and gene therapy"Medvedev S.P., Shevchenko A.I., Zakiyan S.M. (ICiG SB RAS, Novosibirsk, Russia)
POSTER SESSION(Foyer of the 3rd floor, BBA)
November 18th(Large Biological Audience (BBA)
PLENARY REPORTS09.00-9.40
"Metagenomic studies of human microbiota"Shestakov S.V., Lomonosov Moscow State University
9.40-10.20
"Solving the problems of epidemiology based on genomic and postgenomic analysis of strains of pathogenic microorganisms"Ginzburg A.L., Voronina O.L., N.F. Gamalei Research Institute of Epidemiology and Microbiology of the Ministry of Health and Social Development
10.20-11.00
"Regenerative medicine: successes, problems and prospects for the use of therapeutic genes and stem cells"Tkachuk Vs.A., Lomonosov Moscow State University
Break 11.00 – 11.1011.10-11.50
"Telomerase as a basis for biomedical applications"Dontsova O.A., Lomonosov Moscow State University
11.50-12.30
"Approaches to genetic cancer surgery"Sverdlov E.D., Institute of Bioorganic Chemistry named after
Academicians M.M. Shemyakin and Yu.A. Ovchinnikov of the Russian Academy of Sciences
12.30-13.10
"Biological microchips for medical diagnostics"Makarov A.A., Sessatelev A.S., V.A. Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
breakBREAKOUT SESSIONS
(Large Biological Audience (BBA)
SECTION 2. PROTEOMICS AND NEW MARKERS FOR CLINICAL DIAGNOSISModerators:
Ivanov V.T., Institute of Bioorganic Chemistry named after Academicians M.M. Shemyakin and Yu.A. Ovchinnikov of the Russian Academy of Sciences
Moshkovsky S.A., V.N. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences
E.N. Nikolaev, V.N. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences14.30 – 14.50
"Mass spectrometric methods in proteomic studies: human urine proteomics"Nikolaev E.N., Popov I.A., Kononikhin A.S., Moshkovsky S.A., Agron I.A., Avtonomov D.M. (IBHF RAS, IBMH RAMS, Moscow, Russia)
14.50 – 15.10
"Observation of molecular evolution in a Petri dish by mass spectrometry"Matt McKay (Macquarie University, Sydney, Australia), Volker Kruft (Darmstadt, Germany), Keith Ashman (National Cancer Research Center (CNIO), Madrid, Spain)
15.10 – 15.30
"Development of new approaches of comparative proteomic analysis to study the properties of Alzheimer's disease peptide"Kozin S.A., Popov I.A., Kononikhin A.S., Indykina M.I., Kharybin O.N., Nikolaev E.N., Makarov A.A. (IMB RAS, Moscow, Russia)
15.30 – 15.50
"Analysis of the peptidome of arthropod poisons: search for biologically active compounds for medicine and biotechnology"Vasilevsky A.A., Grishin E.V. (IBH RAS, Moscow, Russia)
15.50 – 16.10
"Mass spectrometric profiles of blood plasma for the diagnosis of malignant tumors: present and prospects"Moshkovsky S.A., Karpova M.A., Sokolova E.E., Archakov A.I.
(IBMH RAMS, Moscow, Russia)
Break 16.10-16.2516.25 – 16.45
"The use of mass spectrometry to detect peptide markers of socially significant human diseases in blood serum"Ziganshin R.H., Arapidi G.P., Azarkin I.V., Govorun V.M., Ivanov V.T. (IBH RAS, Moscow, Russia)
16.45 – 17.05
"Proteomic analysis of human DNA repair systems using reactive probes"Lavrik O.I. (IHBFM SB RAS, Moscow, Russia)
17.05 – 17.25
"Mass spectrometric search and identification of kidney cancer markers in human blood plasma" Kovalev S.V., Shevchenko V.E., Zaridze D.G. (Research Institute of Carcinogenesis of the Russian Academy of Medical Sciences, Moscow, Russia)
17.25 – 17.45
"Applied Bioinformatics in the Human Proteome project" Lisitsa A.V., Ponomarenko E.A., Chernobrovkin A.L., Archakov A.I. (IBMH RAMS, Moscow, Russia)
17.45 – 18.05
"Proteomic technologies and the search for new markers for prostate cancer diagnosis"Shishkin S.S., Kovalev L.I., Kovaleva M.A., Ivanov A.V., Lisitskaya K.V., Eremina L.S., Sadikhov E.G., Toropygin I.Yu., Moshkovsky S.A. (INBI RAS, Moscow, Russia)
18.05 – 18.25
"Immunoproteasome as a target for targeted action of low molecular weight inhibitors in a new strategy for the treatment of autoimmune pathologies"Belogurov A.A. (IBH RAS, Moscow, Russia)
Break 18.25-18.4018.40 – 18.55
"Systemic analysis of the human leukemia cell line: transcriptomics, proteomics, metabolomics"Zgoda V.G., Tikhonova O.V., Kurbatov L.K., Kopylov A.T., Moskaleva N.V., Yurasova O.V., Argentova V.V., Novikova S.A., Archakov A.I. (IBMH RAMS, Moscow, Russia)
18.55 – 19.15
"Analysis of the interindividual variability of the blood proteome of a healthy person"Trifonova O.P., Pakharukova N.A., Pastushkova L.H., Lisitsa A.V., Moshkovsky S.A., Larina I.M. (IMBP RAS, Moscow, Russia)
19.15 – 19.35
"Immunoproteomic analysis of the autoantigenic repertoire of papillary thyroid cancer: identification of candidate differential diagnostic objects"Belousov P.V., Kopylov A.T., Tvardovsky A.A., Melnik S.A., Kim Ya.S., Lanshchakov K.V., Vanushko V.E., Moshkovsky S.A., Kuprash D.V., Nedospasov S.A. (Moscow State University, Faculty of Biology, Moscow, Russia)
19.35 – 19.55
"Testing of telomerase activity as a potential universal cancer marker on the example of cervical cancer"Zvereva M.E., Skvortsov D.A., Rubtsova M.P., Korolenkova L.I., Pavlova L.S., Kiselev F.L., Dontsova O.A. (Moscow State University, Faculty of Chemistry, Moscow, Russia)
(Department of Human and Animal Physiology)
SECTION 5. POSTGENOMIC TECHNOLOGIES IN THE CREATION AND VALIDATION OF MEDICINAL COMPOUNDSModerators:
Efremov R.G., Institute of Bioorganic Chemistry named after Academicians M.M. Shemyakin and Yu.A. Ovchinnikov of the Russian Academy of Sciences
Poroikov V.V., V.N. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences
Shaitan K.V., Faculty of Biology, Lomonosov Moscow State UniversityChairmen: A.A. Kamensky, A.V. Feofanov
14.30 – 14.50
"Identification of promising pharmacological targets and their ligands for breast cancer therapy"Poroikov V.V. (IBMH RAMS, Moscow, Russia)
14.50 – 15.10
"Assessment of the activity of chemical compounds by methods of bioinformatics and plasmon resonance"Tumanyan V.G. (IMB RAS), Ivanov A.S. (IBMH RAMS), Shaitan A.K. (MSU), Vlasov P.K. (IMB RAS), Nikolaev I.N. (YSU), Shaitan K.V. (MSU) (Moscow, Yakutsk, Russia)
15.10 – 15.30
"New thrombin inhibitors or how computer drag design can speed up the first stages of screening hundreds of times"Ataullakhanov F.I. (SSC RAMS, CTPFHF RAS), Sinauridze E.I., Sulimov V.B. (MSU) (Moscow, Russia)
15.30 – 15.50
"Design of a highly selective poly inhibitor (ADP-ribose)-polymerases in silico"Nilov D.K. (MSU), Mikhailov S.N., Tararov V.I. (IMB RAS), Zakharenko A.L., Lavrik O.I. (IHBFM SB RAS), Shvyadas V.K. (MSU) (Moscow, Russia)
Break 15.50 – 16.05Chairmen: F.I. Ataullakhanov, V.G. Tumanyan
16.05 – 16.25
"Preclinical trials in vivo – the basis for creating safe medicines"Kamensky A.A. (Moscow State University, Moscow, Russia)
16.25 – 16.45
"Antibody analogues based on alternative scaffold proteins"Petrovskaya L.E., Shingarova L.N., Dolgikh D.A., Kirpichnikov M.P. (Moscow State University, IBH RAS, Moscow, Russia)
16.45 – 17.05
"Development of an innovative drug for the treatment of CNS disorders"Kazey V.I. (Central Research Center "HimRar", Moscow, Russia)
17.05 – 17.25
"Properties of polyplex nanoparticles based on polyethylenimine correlating with their ability to transfect cells"Sobolev A.S. (MSU, IBG RAS, Moscow, Russia)
17.25 – 17.45
"Medicinal systems of antitumor action based on polyoxyalkanoates"Bonartsev A.P., Shaitan K.V. (Moscow State University, Moscow, Russia)
(Audience – "M-1")
SECTION 8. TECHNOLOGIES AND RULES OF BIOMEDICAL RESEARCHModerators:
Samokhodskaya L.M., Lomonosov Moscow State University
Sergienko V.I., Research Institute of Physico-Chemical Medicine of the FMBA of Russia
Radzinsky V.E., Peoples' Friendship University of Russia14.30 – 14.50
"Methodological continuity of preclinical and clinical studies"Sergienko V.I. (Research Institute of FHM FMBA of Russia, Moscow, Russia)
14.50 – 15.10
"Problems and rules of organization of biomedical research"Meshkov A.N. (RKNPC of the Ministry of Health and Social Development, Moscow, Russia)
15.10 – 15.30
"Ethical aspects of biomedical research"Bulaeva K.B. (IOGen RAS, Moscow, Russia)
15.30 – 15.50
"Features of clinical trials of medicines for pregnant women. Presentation of the form "Medicines in obstetrics and gynecology 2010"Radzinsky V.E. (RUDN, Moscow, Russia)
Break 15.50 – 16.0516.05 – 16.25
"Achievements and problems of in vitro fertilization technologies"Shafei R.A. (Moscow State University, Moscow, Russia)
16.25 – 16.45
"Moral, ethical and legal features of cellular technologies"Vasiliev A.V., Chupikova N.I., Terskikh V.V. (IBR RAS, Moscow, Russia)
16.45 – 17.05
"The problem of the status of the human embryo in modern medicine and philosophical anthropology"Hieromonk Dimitri (Pershin) (Moscow State University, Moscow, Russia)
17.05 – 17.25
"Management in translational research (on the example of the Men's Health program)"Peshkov M.N. (Research Institute of FHM FMBA of Russia, Moscow, Russia)
17.25 – 17.45
"Problems of modern biotechnological research"Y.V. Remnev (Temp Center for New Medical Technologies, Moscow, Russia)
(Department of Human and Animal Physiology)
SECTION 10. NANOBIOTECHNOLOGYModerators:
Bykov V.A., "Nanotechnology-MDT"
Ivanov Yu.D., V.N. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences
D.V. Klinov, Institute of Bioorganic Chemistry named after Academicians M.M. Shemyakin and Yu.A. Ovchinnikov of the Russian Academy of Sciences14.30 – 14.50
"Possibilities of probe microscopy for diagnostics and research of biological objects using the new INTEGRA-Life research complex"Bykov V.A., Polyakov V.V. (SE "NT-MDT", Moscow, Zelenograd, Russia)
14.50 – 15.10
"Investigation of biopolymers with spatial resolution up to 1 nm by scanning probe microscopy"D.V. Klinov (IBH RAS, Moscow, Russia)
15.10 – 15.30
"Electrochemistry in biotechnology: sensory systems for the study of bioaffin interactions"Shumyantseva V.V., Bulko T.V., Suprun E.V., Archakov A.I. (IBMH RAMS, Moscow, Russia)
Break 15.30 – 15.4515.45 – 16.05
"AFM-monitoring of the functioning of single enzyme molecules"Ivanov Yu.D., Bukharina N.S., Pleshakova T.O., Krokhin N.V., Archakov A.I. (IBMH RAMS, Moscow, Russia)
16.05 – 16.25
"Development of bionanoscopy equipment for solving medical diagnostics problems"Yaminsky I.V. (Moscow State University, Center for Advanced Technologies, Moscow, Russia)
16.25 – 16.45
"Terahertz radiation: problems and prospects of application for bionanotechnology"Peltek S.E., Popik V.M., Kulipanov G.N., Kolchanov N.A. (ICiG SB RAS, Novosibirsk, Russia)
(Auditorium # 557)
SECTION 11. GENETICS AND TRANSLATIONAL MEDICINEModerators:
Yankovsky N.K., N.N. Institute of General Genetics Vavilova RAS
Filippenko M.L., Institute of Chemical Biology and Fundamental Medicine SB RAS14.30 – 14.50
"Recent advances in predicting the genetic risks of complex diseases"C. Janssens (Cecile Janssens) (Erasmus University Medical Center, Rotterdam, Netherlands)
14.50 – 15.10
"Genetic testing in "risks": useful and useless" Filipenko M.L., Boyarskikh U.A., Voronina E.N., Kudryavtseva E.N., Kel A.E. (IHBFM SB RAS, Novosibirsk, Russia)
15.10 – 15.30
"Genetic methods of screening and diagnosis of colorectal cancer"Kostin P.A., Zakharzhevskaya N.B., Weather T.V., Generozov E.V., Govorun V.M. (Research Institute of FHM FMBA of Russia, Moscow, Russia)
15.30 – 15.50
"Personalized genetic tests. The possibilities of translating genetic knowledge into practical medicine"Generozov E.V., Govorun V.M. (Research Institute of FHM FMBA of Russia), Gilyarov M.Yu. (First MGMU of the Ministry of Health and Social Development), Podzolkova N.M. (DPO RMAPO Roszdrav), Mondoeva S.S., Sukhanova G.A. (GU SSC RAMS) (Moscow, Russia)
Break 15.50 – 16.0516.05 – 16.25
"Genetic factors in risk assessment of patients with acute coronary syndrome" Zateyshikov D.A. (Educational and Scientific Medical Center of the UDP of the Russian Federation), Nosikov V.V. (GosNIIgenetics) (Moscow, Russia)
16.25 – 16.45
"Molecular genetics of type 1 diabetes mellitus"Nosikov V.V. (GosNIIgenetics), Kuraeva T.L. (ENTS RAMS), Nikitin A.G. (GosNIIgenetics), Peterkova V.A., Dedov I.I. (ENTS RAMS) (Moscow, Russia)
16.45 – 17.05
"Evaluation of genetic testing data of hereditary predisposition to multifactorial diseases" Glotov A.S., Glotov O.S., Vashukova E.S., Ivashchenko T.I., Zainullina M.S., Baranov V.S. (NIIAG NWO RAMS, St. Petersburg, Russia)
17.05 – 17.25
"New molecular methods in the evaluation of platelet function and the effectiveness of antiplatelet agents"Sirotkina O.V. (PIAF RAS, Gatchina, Russia)
17.25 – 17.45
"Expression of dopaminergic neurotransmission genes in alcohol dependence syndrome" Taraskina A.E. (PIAF RAS, Gatchina, Russia)
17.45 – 18.05
"Trends in the development of immunogenetics in the post-genomic era"Kofiadi I.A. (Institute of Immunology, Moscow, Russia)
18.05 – 18.25
"The effect of the PrP protein on the aggregation of amyloid peptide BETA causing Alzheimer's disease"Galkin A.P., Magomedova Z.M., Rubel A.A., Saifitdinova A.F., Inge-Vechtomov S.G. (SPbF IOGen RAS, Saint Petersburg, Russia)
18.25 – 18.45
"Analysis of genetic and phenotypic diversity using Affymetrix technologies"Kirillov V.A., Zhernovkov V.E. (Helicon, Moscow, Russia)
(Foyer of the 3rd floor, BBA)
POSTER SESSIONNovember 19
(Large Biological Audience (BBA)
PLENARY REPORTS 9.00-9.40
"Molecular bioengineering of new medicines"Kirpichnikov M.P., Lomonosov Moscow State University
9.40-10.20
"Molecular epidemiology – new perspectives in the study of the etiology and pathogenesis of malignant tumors"D.G. Zaridze, N.N. Blokhin Russian Cancer Research Center
10.20-11.00
"System Computer Biology"Kolchanov N.A., Institute of Cytology and Genetics SB RAS
Break 11.00 – 11.1011.10-11.50
"New integrated platforms for biomedical research in microbiology and genetics"Govorun V.M., Research Institute of Physico-Chemical Medicine of the FMBA of Russia, RSC "Kurchatov Institute", Institute of Bioorganic Chemistry named after
Academicians M.M. Shemyakin and Yu.A. Ovchinnikov of the Russian Academy of Sciences
12.00-12.40
"Clinical expectations of "smart" technologies. Problems of translational medicine"Puzyrev V.M., Research Institute of Medical Genetics SB RAMS
12.40-13.20
"Fluorescent proteins for biomedical research"Lukyanov S.A., Institute of Bioorganic Chemistry named after
Academicians M.M. Shemyakin and Yu.A. Ovchinnikov of the Russian Academy of Sciences
13.20-14.30
Satellite SymposiumParticipating companies: Bio-rad, Spectronica, Biovitrum, Olympus, DNA technologies
"Multiplex technologies for solving typical post-genomic problems"Telkov M.V., Candidate of Biological Sciences, Bio-Rad Laboratories, Moscow
"Pharmacogenomics as the leader of personal genetic testing"Rebrikov D.V., Doctor of Biological Sciences, CJSC "NPF DNA Technology" , Moscow
"New generation sequencing. Technologies, achievements, areas of application"Kwon D.A., Candidate of Biological Sciences, LLC "Spectronika", Moscow
"Modern Nikon hardware solutions in optical microscopy for biological research"Zykov P.A., specialist in microscopy, LLC "BioVitrum M", Moscow
BREAKOUT SESSIONS(Large Biological Audience (BBA)
SECTION 3. POSTGENOMIC TRENDS IN CLINICAL MICROBIOLOGYModerators:
Ilyina E.N., Research Institute of Physico-Chemical Medicine of the FMBA of Russia
Kozlov R.S., Research Institute of Antimicrobial Chemotherapy
Narodnitsky B.S., N.F. Gamalei Research Institute of Epidemiology and Microbiology of the Ministry of Health and Social Development
M.V. Eidelstein, Research Institute of Antimicrobial Chemotherapy14.30 – 14.50
"Molecular epidemiology of pneumococci" Sidorenko S.V. (Research Institute of Pediatric Infections of the FMBA of Russia, St. Petersburg, Russia)
14.50 – 15.10
"MALDI Biotyper – progress towards accurate identification of microorganisms in clinical laboratories"Kostertseva M. (Kostrzewa Markus) ("Bruker Daltonik GmbH", Bremen, Germany)
15.10 – 15.30
"Human microbiome: research strategy, problems in groups of people working in extreme conditions"Danilenko V.N. (IOGen RAS, Moscow, Russia)
15.30 – 15.50
"Genomic studies of plasmid resistance in gram-negative bacteria"A. Carattoli ("ISS", Rome, Italy)
15.50 – 16.10
"Metallo-beta-lactamases of gram-negative bacteria: genetics and molecular epidemiology"M.V. Eidelstein (NIIAH SGMA, Smolensk, Russia)
Break 16.10 – 16.2516.25 – 16.45
"Phage lysines of staphylococci"Abaev I.V. (SSCPMB of the Ministry of Health and Social Development, Obolensk, Russia)
16.45 – 17.05
"Analysis of bacterial and viral genomes using hydrogel biochips and microfluidic systems for automated processing of biological samples"Grydunov D. (IMB RAS, Moscow, Russia)
17.05 – 17.25
"DNA microchips with colorimetric detection for the diagnosis of resistance of microorganisms to beta-lactam antibiotics"Rubtsova M.Yu. (Moscow State University, Moscow, Russia)
17.25 – 17.45
"Modern methods – new opportunities for medical virology"Prilipov A.G. (Institute of Virology of the Russian Academy of Medical Sciences, Moscow, Russia)
17.45 – 18.05
"From basic research to nanotechnology: the case of the West Nile virus"Razumov I.A., Pereboev A.V., Borisevich V., Tsuladze G., Shakhmatov M., Khudman D., Kazachinskaya E.I., Svyatchenko V.A., Yamshchikov V., Loktev V.B., Oshchepkov D.Yu. (ICiG SB RAS, Novosibirsk, Russia)
(Department of Human and Animal Physiology)
SECTION 5. POSTGENOMIC TECHNOLOGIES IN THE CREATION AND VALIDATION OF MEDICINAL COMPOUNDSModerators:
Efremov R.G., Institute of Bioorganic Chemistry named after Academicians M.M. Shemyakin and Yu.A. Ovchinnikov of the Russian Academy of Sciences
Poroikov V.V., V.N. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences
Shaitan K.V., Faculty of Biology, Lomonosov Moscow State University
Chairmen: Shaitan K.V., Poroikov V.V.
14.30 – 14.50
"Application of molecular modeling methods for drug development"Sulimov V.B. (Moscow State University, Moscow, Russia)
14.50 – 15.10
"A new strategy for using antimicrobial peptide genes from arthropod venom as gene therapy agents"Lazarev V.N., Shkarupeta M.M., Polina N.F., Vasilevsky A.A., Kozlov S.A., Grishin E.V., Govorun V.M. (Research Institute of FHM FMBA of Russia, IBH RAS, Moscow, Russia)
15.10 – 15.30
"Modular nanotransporters – a new multi-purpose platform for drug delivery in vivo"Sobolev A.S. (MSU, IBG RAS, Moscow, Russia)
15.30 – 15.50
"Cyclotechnology. A new approach to the creation of orally active low molecular weight derivatives of peptides and peptidomimetics"Deigin V.I.
(IBH RAS, Moscow, Russia)
Break 15.50 – 16.0516.05 – 18.00
Round table on the topic: "Modeling, targeted delivery systems, validation of medicinal substances"General discussion
(Auditorium # 557)
SECTION 6. CLINICAL LABORATORY DIAGNOSTICS AND POSTGENOMIC TECHNOLOGIESModerators:
Noskin L.A., B.P. Konstantinov St. Petersburg Institute of Nuclear Physics of the Russian Academy of Sciences
Titov V.N., Russian Cardiological Research and Production Complex of Rosmedtechnology of the Ministry of Health and Social Development of the Russian Federation
Emanuel V.L., St. Petersburg State Medical University named after Academician I.P. Pavlov14.30 – 14.50
"Postgenomic diagnostics. Biological bases of improvement of the postanalytical stage of clinical biochemistry"Titov V.N. (RKNPC of the Ministry of Health and Social Development, Moscow, Russia)
14.50 – 15.10
"Polysystem sanogenetic monitoring in predictive diagnostics of dysregulatory pathologies. The fundamental foundations of individual sanotyping"
Noskin L.A. (PIAF RAS), Karganov M.Yu. (URAMN Research Institute of OPP RAMS) (Gatchina, Moscow, Russia)
15.10 – 15.30
"The effectiveness of the use of molecular technologies in clinical diagnostics as the goal of the educational process of a medical university (or reflections at the front door)"Emanuel B.L. (SPbSMU, Saint Petersburg, Russia)
15.30 – 15.50
"Investigation of oligomeric forms of Tamma-Horsfall protein in healthy people and patients with urolithiasis"Landa S.B. (PIAF RAS), Emanuel V.L. (SPbSMU), Egorov V.V. (Influenza Institute of the NWO RAMS) (Gatchina, St. Petersburg, Russia)
Break 15.50 – 16.0516.05 – 16.25
"Flow-cytometric assessment of the dynamics of changes in intracellular levels of nitric oxide and superoxide in normal and after treatment of cells with therapeutic agents"Guiliano N.Ya., Konevega L.V., Stepanov S.I. (PIAF RAS, Gatchina, Russia)
16.25 – 16.45
"Problems of DNA diagnostics of pathogenic fungi in the practice of oncohematology"Chukhlovin A.B., Eismont Yu.A., Shiryaev S.N., Zubarovskaya L.S., Afanasyev B.V. (St. Petersburg State University, Saint Petersburg, Russia)
16.45 – 17.05
"Standardization of quantitative laboratory research – policy of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC)"Moshkin A.V. (Institute of Neurosurgery of the Russian Academy of Medical Sciences, Moscow, Russia)
17.05 – 17.25
"New genomics information technologies to help practical healthcare"Baranov V.S. (NIIAG NWO RAMS, St. Petersburg, Russia)
17.25 – 17.45
"Molecular genetic analysis of the risk of habitual miscarriage"Samokhodskaya L.M., Sadekova O.N. (Moscow State University, Moscow, Russia)
(Audience – "M-1")
SECTION 7. BIOINFORMATICS TECHNOLOGIESModerators:
Kolchanov N.A., Institute of Cytology and Genetics SB RAS
Bulinsky A.V., Lomonosov Moscow State University 14.30 – 15.00
"Data analysis and modeling of the epidemic process of socially significant infections (tuberculosis, HIV, ARVI)"Romaniukha A.A. (IVM RAS), Nosova E.A. (NCNIIOIZ of the Ministry of Health and Social Development), Melnichenko O.A. (MSU), Sannikova T.E. (IVM RAS), Drinov I. D. (NIIEM RAMS) (Moscow, Russia)
15.00 – 15.30
"Probabilistic and statistical methods for identifying sets of polymorphisms that increase the risk of a complex disease"Bulinsky A.V. (Moscow State University, Moscow, Russia)
15.30 – 16.00
"Molecular genetic indices of epidemiological risk and their application to the analysis of tuberculosis incidence in Russia"Rudnev S.G. (IVM RAS), Selitskaya R.P. (NIIFP MMA), Bogorodskaya E.M. (NIIFP MMA named after I.M.Sechenov), Boldyreva M.N. (Institute of Immunology of the FMBA of Russia) (Moscow, Russia)
16.00 – 16.30
"Data analysis and modeling of tuberculosis incidence dynamics in Russia" Romaniukha A.A. (IVM RAS), Melnichenko O.A. (MSU) (Moscow, Russia)
Break 16.30 – 16.4516.45 – 17.05
"Rational design of vaccines for induction of HIV-1-specific CD8+T-lymphocyte response"Bazhan S.I., Karpenko L.I., Ilyicheva T.N., Belavin P.A., Seregin S.V., Antonets D.V., Ilyichev A.A. ("Vector", Koltsovo, Russia)
17.05 – 17.25
"Molecular evolution of animal and fungal cyclins: the relationship between protein changes and the increase in complexity of organisms"Turnaev I.I., Gunbin K.V., Suslov V.V. (ICiG SB RAS), Afonnikov D.A. (NSU) (Novosibirsk, Russia)
17.25 – 18.45
"Computer analysis of metagenomic data: prediction of the quantitative value of specific protein activity"Ivanisenko V.A., Demenkov P.S., Pintus S.S., Ivanisenko T.V., Goncharova N.I., Rozanov A., Bryanskaya A., Kostryukova E.S., Levitsky S.A., Selezneva O.V., Chukin M.M., Larin A.K., Kondratov I.G., Lazarev V.N., Peltek S.E., Govorun V.M. (ICiG SB RAS, Novosibirsk, Research Institute of FHM FMBA of Russia, Moscow, Russia)
18.45 – 19.05
"Computer-experimental study of transcription factor binding sites"Oshchepkov D. Yu. (ICiG SB RAS, Novosibirsk, Russia)
(Foyer of the 3rd floor, BBA)
POSTER SESSION