Genes will determine the risk of coronary heart disease
Scientists have developed a genomic test that determines predisposition to heart attack
This is reported by the BBC Broadcasting Corporation.
"The cost of passing the Genomic Risk Score (GRS) test will be only £40 ($52), which is cheap enough for large–scale screening," the BBC quoted the authors of the study as saying. According to them, the test results will help to find out why people with the absence of obvious risk factors, such as high cholesterol in the blood, can get a heart attack.
This test can be taken at any age, because human DNA does not change throughout a person's life.
Figure from the article Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults, published in the Journal of the American College of Cardiology – VM.
Blood samples are used for the study, but, as scientists say, you can do with a smear from the mouth. 20% of the GRS test participants who were placed at the beginning of the "genomic risk scale" are four times more likely to earn coronary (ischemic) heart disease (CBS) than people who took 20% at the end of it.
The test was developed after analyzing the genomic information of half a million people aged 40 to 69 years, which is contained in the British Biobank (UK Biobank). At the same time, 22 thousand of them had CBS.
A leading researcher from the Baker Institute of Heart and Diabetes (Australia) and the University of Cambridge, Dr. Michael Inouye, said that approximately half of CBS occur for genetic reasons (heredity), and the other half is determined by lifestyle and environment. "We overlooked the genetic component in risk screening. We were in real ignorance about the genetic component," he added.
Since the patient's condition begins to change several decades before the symptoms manifest, it is necessary to determine them significantly earlier, which GRS can do, Professor Nilesh Samani from the University of Leicester (UK) is convinced. In his opinion, the new technology will help doctors to divide patients into those who will benefit from additional intervention and those who clearly do not need various types of screening.
Dr Inouye added that "there is still a lot of work to be done" before the test is implemented in healthcare systems, particularly in the UK, in order to improve the accuracy of GRS.
According to the World Health Organization, cardiovascular diseases account for the largest share in the structure of mortality from non-communicable diseases (17.7 million people per year). They are followed by oncological diseases (8.8 million cases), respiratory diseases (3.9 million) and diabetes (1.6 million). In the UK, more than 66 thousand people die from cardiovascular diseases every year.
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