Chondrogenesis in nanocars
Stem cell drug triggers rapid cartilage regeneration
Svetlana Maslova, Hi-tech+
Scientists have developed special nanocars that not only trigger accelerated tissue regeneration, but also fight inflammation at the site of injury. The excellent results obtained on preclinical models have shown that the new technology can become a universal tool for tissue engineering.
Cartilage tissue has an extremely low ability to regenerate, therefore, despite the significant success of the use of stem cells in regenerative medicine, it is still very difficult to restore cartilage. In search of a solution to the problem, a group of researchers from the United States worked with stem cells, but created a 3D nanocarp based on them.
Article by Wang et al. Injectable Hybrid Organic nanoscaffold as rapid stem cell assembly template for cartage repair is published in the journal National Science Review – VM.
The 3D-IHI nanocarcass rapidly assembles stem cells into tissue structures for injection due to adapted three-dimensional cell-cell and cell-matrix interactions, writes Phys.org . As a result, this makes it possible to deliver chondrogenic proteins deeply and uniformly into the assembled systems of a three-dimensional culture and induce chondrogenesis, the authors explain.
In experiments on rabbits, scientists have shown that stem cell injections effectively modulate the microenvironment necessary to trigger cartilage regeneration, and simultaneously remove reactive oxygen species, reducing inflammation. They noted rapid regeneration and restoration of tissue function in the short and long term.
The damaged cartilage was fully restored in three months – VM.
"Given its excellent versatility and therapeutic outcome, the technology could become a promising tool for various areas of tissue engineering," the researchers concluded. Meanwhile, there is still a lot of work ahead, which should prove the potential and safety of such treatment for humans.
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