Patch-vaccine: work continues
Flu vaccine in the form of a patch will replace injections
Copper news based on the materials of Science Daily: Could dissolvable microneedles replace injected vaccines?The staff of Osaka University proposed (two years ago – VM) to use patches with microneedles containing an active component for vaccination against the influenza virus.
Scientists believe that this method will allow patients to avoid the painful sensations that standard immunization causes.
Most vaccines are injected either under the skin or into muscle tissue, so this method of administration of the drug can lead to infection. Japanese scientists have proposed replacing injections with the use of a MicroHyala patch.
On the surface of the patch there are soluble microscopic needles made of hyaluronic acid, in which the drug is located. It is important that the use of the vaccine does not require the participation of a physician. Thus, MicroHyala can be used in developing countries where there is a shortage of doctors and nurses.
The authors of the study compared the effect of the patch and conventional vaccines when immunizing volunteers against three strains of influenza virus: A/H1N1, A/H3N2 and B. According to the results, all volunteers successfully underwent vaccination. At the same time, both methods of vaccination contributed to the development of approximately the same immune response. "We were pleased to see that the new patch is as effective as conventional injectable vaccines. At the same time, the new form of the drug is safe for use," said the head of the study, Shinsaku Nakagawa.
Article by Hirobe et al. Clinical study and stability assessment of a novel transcutaneous influenza vaccination using a dissolving microneedle patch is published in open access in the journal Biomaterials – VM.
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16.07.2015