Only olive oil!
Mice with Alzheimer's were fed rapeseed oil for six months. They didn't get any better
Elizaveta Ivtushok, N+1
Rapeseed oil does not help alleviate the symptoms of Alzheimer's disease, American scientists have found. They kept mice on a diet for six months, where the main source of fat was rapeseed oil, popular in the USA and Canada, while previous experiments showed that olive oil can have a beneficial effect in this case. The results of the study are described in an article published in the journal Scientific Reports.
A key role in the mechanism of neurodegeneration in Alzheimer's disease is played by the accumulation of pathological forms of proteins in the brain of patients: beta-amyloids in the form of insoluble plaques and hyperphosphorylated tau proteins in the form of neurofibrillary tangles (clusters). Experiments on mice have shown that diet plays an important role in the nature of the course of this disease: for example, the use of olive oil as the main source of vegetable fats reduces the amount of pathological protein. In addition, the consumption of olive oil reduces the risk of dementia in old age.
Elisabetta Lauretti and Domenico Pratico from Temple University (Philadelphia, USA) studied how another source of vegetable fats, rapeseed oil, affects the course of Alzheimer's disease. To do this, they took two groups of transgenic mice with Alzheimer's disease (12 in the experimental group and 10 in the control group), and rapeseed oil was added to the diet of the first of them. The experiment took place for six months, after which the scientists measured the weight of mice, checked their cognitive abilities and the accumulation of pathological proteins in their brains.
At the end of the experiment, the scientists found that the mice on a diet with rapeseed oil weighed seven grams more than their relatives from the control group. The cognitive abilities of mice were tested during three different experiments on working memory and spatial attention. During the first, the mice had to find a reward in one of the arms of the Y-shaped maze, in the second — to explore a small room, in certain parts of which there were triggers that let an electric current. During the third and last experiment, the mice had to find a platform in a deep pool.
In general, behavioral data did not show a statistically significant difference in the cognitive functions of mice from the experimental and control groups: scientists found a significant (p<0.05) difference only in the number of alternations of the maze arms. Mice on a rapeseed diet were much less likely to change the sleeve of the maze if they did not find a reward there.
As for the analysis of pathological forms of proteins, the scientists found in the brains of mice from the active experimental group an increase in the concentration of Aß42 peptide, a pathological form of beta—amyloid proteins; however, such an increase (compared with the control group) had no statistical significance. The scientists did not find any differences in the accumulation of neurofibrillary tangles.
Despite the fact that studies need to be carried out further to statistically confirm the results of the experiment, the authors of the work insist that the use of rapeseed oil as a source of vegetable fats does not affect the stopping of the neurodegeneration process.
Portal "Eternal youth" http://vechnayamolodost.ru