Nitric oxide and stroke
Researchers from Russia and Belarus measured the content of toxic oxide in the brain
Nitric oxide performs vital signaling functions in the body, but in some cases too much of it is formed, and it fully manifests its usual toxicity. The level of NO in the brain after a stroke was measured by scientists from Russia and Belarus.
Nitrogen monoxide NO is a poisonous gas, but in extremely small quantities it is necessary for life for both humans and other organisms, including fungi and plants. This is a rare example of a gas transmitter involved in short-term intracellular and intercellular communications, for example, in the immune response, vascular relaxation and stimulation of blood flow.
On the other hand, excess NO is formed in ischemic heart disease and other acute circulatory disorders. Reacting with peroxide and other active forms of oxygen, the "excess" nitric oxide turns into an extremely toxic and strong oxidizer peroxynitrite, which easily damages neighboring cells and tissues.
In order to find out how the dynamics of NO synthesis in brain cells changes under such conditions, researchers from Kazan (Volga Region) Federal University (KFU) and their colleagues from the National Academy of Sciences of Belarus experimented on laboratory rats in which an attack of ischemic (with impaired blood supply) or hemorrhagic (with intracerebral hemorrhage) stroke was artificially induced.
To directly identify NO in the hippocampus of animals, Khalil Gainutdinov and his colleagues used EPR microscopy, finding that the formation of oxide decreases within five hours after such attacks, decreasing 2-3 times, and remains at this level from 24 to 72 hours. This, according to the authors, indicates a previously unnoticed and important systemic disorder that develops during stroke.
Article by Gainutdinov et al. Participation of NO-synthase in Control of Nitric Oxide Level in Rat Hippocampus after Modeling of Ischaemic and Haemorrhagic Insult is published in the journal BioDiscovery.
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