Hemophilia can be cured by endothelial cell transplantation
American scientists were trying to find liver cells responsible for the production of blood clotting factor VIII, a defect that made some members of the royal families of Europe and Russia so vulnerable to the slightest injury. These changes are transmitted with the female sex chromosome, but only boys suffer from hemophilia.
Transplantation of endothelial cells of the liver sinuses from healthy individuals to mice with a congenital defect of the blood coagulation system was successful. The cells populated the corresponding niche and began to produce a much-needed factor, which restored the coagulation system. This discovery not only solved the question of the source of factor VIII, but also opens up new opportunities for thousands of patients with classical hemophilia around the world.
In more detail with the work of Antonia Follenzi et al. Transplanted endothelial cells repopulate the liver endothelium and correct the phenotype of hemophilia A mice can be found in the Journal of Clinical Investigation.
Portal "Eternal youth" www.vechnayamolodost.ru18.02.2008