Anti-flu patch
The effectiveness of patches for flu vaccination has been proven
American scientists have proven the effectiveness of soluble patches as a new method of vaccination against influenza. In the near future, this method may replace painful injections. The results of the first stage of clinical trials are published in the Lancet medical journal.
The patch contains a vaccine that is injected into the patient's body through the skin using micro needles. This method may have advantages over the conventional grafting method, since there are many antigen-presenting (dendritic) cells in the skin. The latter recognize the antigen (foreign substance) and activate T-lymphocytes to fight it. However, the safety and effectiveness of such vaccines have previously been tested only on animals.
The blind randomized clinical trial involved 100 people aged 18 to 49 years. The volunteers did not suffer from skin diseases and were not vaccinated against influenza in 2014-2015. The subjects were randomly assigned to four groups of equal size. In one group, patients were given injections, and participants in the other three were given patches that either contained the vaccine or were a "dummy" (placebo).
The researchers tracked possible manifestations of adverse reactions for 180 days, and also determined the number of antibodies in the body of volunteers on the 28th day after vaccination.
It turned out that the strongest side effects from the use of patches were hypersensitivity of the skin, redness and itching. At the same time, the effectiveness of the new method of inoculation was not inferior to intramuscular injection. 70 percent of the volunteers who received the vaccine in this way reported that they would prefer patches to painful injections.
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28.06.2017