SkQ1 vs "diabetic foot"
MSU biologists have found a new antioxidant that heals wounds in diabetes
RIA Novosti (ask them where they got such a title – VM).
The staff of the Faculty of Biology and the A.N. Belozersky Research Institute of Physico-Chemical Biology of Lomonosov Moscow State University tested an antioxidant on a mouse model that helps in the treatment of diabetic wounds. The scientists described the results of their work in an article to be published in the journal Oxidative Medicine and Cellular Longevity (Demyanenko et al., Mitochondria-targeted antioxidant SkQ1 improves dermal wound healing in genetically diabetic mice).
Violation of wound healing is a typical symptom of type 2 diabetes mellitus. Patients spontaneously develop skin lesions on their legs – this phenomenon is called diabetic foot. Such wounds are difficult to treat and become chronic. Currently, there are no effective medicines for the treatment of diabetic wounds. Often the only treatment option is surgery, but even this does not always lead to the desired result. It is also known that diabetes is accompanied by significant oxidative stress, which affects the vessels of diabetic patients. It is assumed that vascular dysfunction in diabetes – diabetic angiopathy – is one of the main causes of impaired wound healing.
"In this work, the effectiveness of the mitochondrial-directed antioxidant SkQ1 was tested on a mouse model of type 2 diabetes. It was found that SkQ1 significantly accelerated wound healing in these animals: it accelerated the epithelization of wounds, the formation of granulation tissue and, which is extremely important for the healing of diabetic wounds, stimulated vascular growth, restoring impaired blood circulation. Experiments on cell cultures, as well as a thorough histological study of these wounds have shown that SkQ1 normalizes almost all the main stages of wound healing, which proves the crucial role of mitochondrial reactive oxygen species in the pathogenesis of diabetic wounds," said one of the authors of the article Roman Zinovkin, PhD, senior researcher at the Department of Mathematical Methods in Biology of Scientific andResearch Institute of Physico-Chemical Biology named after A.N. Belozersky, Lomonosov Moscow State University.
Recall that the mitochondrial antioxidant SkQ1 was developed under the guidance of Academician Vladimir Skulachev– director of the Institute of Physico-Chemical Biology named after A.N.Belozersky. Vladimir Skulachev is known for his scientific works on the prevention of aging of the human body. New studies of this substance give every reason to create an innovative drug – a wound healing gel based on SkQ1 to combat diabetic wounds.
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19.06.2017