21 October 2015

Brain mycosis in Alzheimer's disease

Mushrooms are found in the brain of those who died from Alzheimer's disease


Fungal hyphae was also found in the neurons of 11 people who died of Alzheimer's disease, but was not found in their 11 peers who died for other reasons.

Traces of the presence of fungi are noted both in the nerve cells themselves and in the spaces between them. Most evidence of the presence of fungi was found in the frontal lobes, as well as in the cerebellum and hippocampus. All these structures suffer in the last stages of the disease, and pathological changes appear in the hippocampus among the first. In addition, mushrooms were found in the vascular plexus of the brain. This may explain why patients with Alzheimer's disease often have disorders of the brain vessels.

The presence of fungi was detected by immunohistochemistry (antibodies sensitive to the components of fungi were taken and a solution with them was added to the medium with a sample of nervous tissue). Then samples were taken from the frozen brain of biomaterial donors and subjected to DNA sequencing. Using this method, it was possible to identify specific types of fungi inhabiting the brains of Alzheimer's patients. One of these fungi is Candida glabrata. (In addition to it, the researchers found two more species of the same genus of yeast fungi and one type of soil fungus of the Coelomycete class, Phoma betae, parasitizing beetroot (Latin Beta) – VM).

Anyway, the presence of fungal cells in the brains of patients with Alzheimer's disease does not mean that there is a causal relationship between these organisms and age-related mental pathology. It is possible that the donors of the biomaterial before their death lived in conditions conducive to the growth of fungi and even the development of other infectious diseases. It is impossible to clarify this now.

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21.10.2015
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