False predictions?
In the largest meta-analysis ever conducted, scientists from the University of Alberta have combined data from studies over two decades that focus on the relationship between common gene mutations, also known as single nucleotide polymorphisms (SNPs), and various diseases and conditions. The results show that the relationship between most human diseases and genetics is, to put it mildly, questionable.
In other words, DNA does not determine a person's fate, and snips falsely predict morbidity. David Scott Wishart, professor of the Department of Biological Sciences at the University of Alberta and head of the study, writes that the vast majority of diseases, including many types of cancer, diabetes and Alzheimer's disease, at best depend on genetic factors by 5-10 percent.
The study also highlights some notable exceptions, including Crohn's disease, celiac disease and age-related macular degeneration, the genetic factor in the development of which is approximately 40 to 50 percent.
Despite these rare exceptions, it is becoming increasingly clear that the risk of disease in most cases is associated with metabolism, the environment, lifestyle, or exposure to various types of nutrients, chemicals, bacteria or viruses.
That's why Wishart and his colleagues say that analyzing metabolism, chemical levels, proteins, or microbiome composition provides a much more accurate basis for measuring disease risk, and is also more reliable for diagnosis. The results obtained contradict many modern business models of genetic testing, which claim that genome analysis can accurately predict the risk of serious diseases of anyone. This study also highlights the need to understand the safety of the environment, the quality of our food, air and water.
Article by J.Patron et al. Assessing the performance of genome-wide association studies for predicting disease risk published in the journal PLOS One.
Aminat Adzhieva, portal "Eternal Youth" http://vechnayamolodost.ru according to the materials of the University of Alberta: Your DNA is not your destiny—or a good predictor of your health.