Deacetylases are to blame for aging
A new aging mechanism has been found
Scientists from the Vienna Veterinary University and the Vienna Medical University have identified a new mechanism of aging, which is caused by a decrease in the activity of histone deacetylases. These compounds catalyze the removal of acetyl groups in histones – nuclear proteins involved in the packaging of DNA strands and the regulation of gene activity. This is reported in the press release Important aging mechanism in fish model Nothobranchius furzeri revealed.
Researchers have discovered the mechanism in fish Notobranch Furzer (Nothobranchius furzeri), whose life expectancy is only 3-4 months. These animals age quickly, and age-related diseases begin to manifest themselves early, including degeneration of the nervous system and cancer.
Biologists have shown that the level of deacetylases decreases with aging, which leads to increased synthesis of CDKN1A, a cyclin–dependent kinase inhibitor protein that is involved in the cellular response to DNA damage. The same was observed in the cells of aging mice.
According to scientists, the results of the study demonstrate that aging is closely related to the epigenetic regulation of the cell cycle and is programmed by evolution. Changes in the activity of genes in this case can be reversible. The researchers believe that in the future it will be possible to develop compounds capable of enabling this mechanism.
Article by Zupkovitz et al. Histone deacetylase 1 expression is inversely correlated with age in the short-lived fish Nothobranchius furzeri published in the journal Histochemistry and Cell Biology – VM.
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