Oxidation and aging

Researchers from Marshall University (USA) have determined that the oxidative amplification loop of Na/K-ATPase (Na/K-ATPase oxidant amplification loop, NKAL) is closely related to the aging process and can serve as a target for anti-aging interventions. They also demonstrated the therapeutic potential of the synthetic peptide pNaKtide to restore physiological functions and slow down the aging process.

In a large multi-year study, the authors studied old mice that were fed an adaptation of the Western diet to stimulate oxidative stress and activate NKAL. As a result, the mice showed functional and structural signs of aging. The introduction of the pNaKtide peptide slowed down these changes. The same results were obtained in human cell culture. Dermal fibroblasts were exposed to various types of oxidative stress, which stimulated NKAL, increased the expression of aging markers and led to cell damage. With the introduction of pNaKtide, the negative phenomena associated with aging were significantly weakened.

Unlike well-known antioxidants (N-acetylcysteine, vitamin E), which also reduce overall oxidative stress, pNaKtide provided better protection against free radicals, apparently due to greater action in the cell nucleus.

The data obtained indicate that the oxidative amplification loop of Na/K-ATPase is closely related to the aging process. If this is confirmed in clinical studies, NKAL may become a target for the treatment of age-related diseases.

It is necessary to conduct safety studies of pNaKtide for humans and consider the possibility of its use against clinical signs of aging.

Article by K. Sodhi et al. The Na/K-ATPase Oxidant Amplification Loop Regulates Aging is published in the journal Scientific Reports.

Aminat Adzhieva, portal "Eternal Youth" http://vechnayamolodost.ru Based on EurekAlert: Marshall School of Medicine research team defines possible anti-aging intervention.