Cardiovascular disease risk depended on blood glucose levels
The risk of cardiovascular disease appeared to be increased in people with prediabetes as well as those with diagnosed and detected disease. At the same time, patients with glycemia levels closer to the lower limit of normal were less likely to develop cardiovascular disease.Scientists from the London School of Hygiene and Tropical Medicine have established a relationship between the concentration of glucose in the blood and the risk of cardiovascular disease. The results of the study were published in The Lancet.
An age-adjusted analysis showed that people with prediabetes had a 30% increased likelihood of cardiovascular complications and a 47% increased risk of cardiovascular complications if undiagnosed. The highest risk was observed in women with diagnosed diabetes - it turned out to be doubled. In men with diagnosed disease, the risk increased by 55%.
At the same time, compared to participants with normal blood glucose levels, the probability of cardiovascular complications in people with glycemia approaching the lower limit of normal was 10% lower.
Part of the increased cardiovascular risk in both men and women was attributed to the influence of modifiable factors. To reduce risk, weight should be monitored, and hypotensive agents and statins should be taken, the researchers noted.
Analyzed the level of glycemia more than 400 thousand people from the UK Biobank database. Participants were divided into groups based on glucose concentration: low normal (below 35 mmol/mol), normal (35-41 mmol/mol), prediabetes (42-47 mmol/mol), undiagnosed diabetes (≥48 mmol/mol) and diagnosed diabetes. The researchers assessed the risk of cardiovascular disease as a function of blood glucose concentration.