"Human proteome": the Russian part is practically completed
Russian scientists have studied all the main proteins of the 18th chromosome
Russian scientists within the framework of the international project "Human Proteome" have successfully completed an inventory of the main proteins encoded by the genes of the 18th human chromosome, Elena Ponomarenko, head of the laboratory for analysis of postgenomic data of the Orekhovich Research Institute of Biomedical Chemistry of the Russian Academy of Medical Sciences, told RIA Novosti.
"Russia has chosen the 18th chromosome as part of an international project and, according to the roadmap, the study of the main (unmodified) proteins should be completed by the end of 2013, which was done," the agency interlocutor said.
The Human Proteome project has been running since 2010 and is a large-scale continuation of the Human Genome project completed in 2001. In accordance with the chromosome-centric approach, the main goal of the Human Proteome project is to inventory all human proteins and find out the interactions between them. It is assumed that the accumulated knowledge will contribute to the creation of cheap and affordable methods of early diagnosis.
More than 90% of the proteins encoded on the 18th chromosome (250 out of 277) were identified in samples (blood plasma, human liver cells and HepG2 cells) by November of this year by the participants of the Russian consortium. These results are presented in a report publication in the Journal of Proteome Research. In November and December, 18 additional proteins were detected using a modified sample preparation protocol.
"At the moment, only 9 proteins out of 277 have not been detected. Probably, this is a consequence of the lack of sensitivity of analytical methods, the lack of expression of these proteins in the selected types of biomaterial or some other reasons - it is still unknown," Ponomarenko said.
The Human Proteome project is designed for a period up to 2020, and by that time scientists plan to study modified forms of proteins as well.
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