Once again about the benefits of resveratrol
Red wine helped scientists figure out how to resist old age
Scientists Find Clues to Aging in a Red Wine Ingredient’s Role in Activating a ProteinNicholas Wade, The New York Times, November 26, 2008
Translation: InopressaWe are talking about the beneficial effects of resveratrol – a substance that is contained in small amounts in red wine – on the health and life expectancy of laboratory mice.
The results of the study, carried out by a group led by David Sinclair from the Harvard School of Medicine, are published on Wednesday on the website of the journal Cell.
With age, the integrity of chromosomes in the body is disrupted, but resveratrol heals them by activating the sirtuin protein. Biologists are expanding efforts to study sirtuins and other potent substances that control the "settings" of metabolism in a living cell – for example, the processing of fats and the reaction to insulin, the newspaper notes.
Sirtris, co-founded by Sinclair, has developed a number of drugs that act like resveratrol. According to a report in the November issue of the journal Cell Metabolism, one of these drugs prevents obesity in mice that eat fatty foods, and also increases their endurance to physical exertion – just like resveratrol.
However, it should be remembered that resveratrol is a potent substance with a versatile effect, which is far from being reduced to the activation of sirtuin, the author emphasizes.
"Under normal conditions, sirtuin serves to block all the genes that the cell does not need at the moment. However, if both strands of the chromosome break in the DNA, sirtuin holds them together, and then the genes that it blocked create chaos." According to Sinclair and his co-authors, this may be one of the main causes of aging in mice and, probably, humans. In an interview with the newspaper, the scientist stressed that the hypothesis has not yet been proven. Nevertheless, he claims that he has been taking resveratrol in large doses every day for five years and feels great.
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27.11.2008