Another effect of kisspeptin
Osteoporosis is a serious global health problem, it leads to millions of bone fractures worldwide every year. This disease usually occurs when there is a violation of the delicate balance between the activity of cells forming (osteoblasts) and destroying bone (osteoclasts).
Biphosphonates and other modern drugs for the treatment of osteoporosis often have serious side effects, are not suitable for many patients and can only be used for a limited period of time.
In a new clinical study, a group from Imperial College London performed a one-and-a-half-hour infusion of kisspeptin to 26 healthy men. Bone tissue parameters were evaluated in all participants, including a marker of bone activity – osteocalcin. The researchers showed that after administration of kisspeptin, the level of osteocalcin increased by 24% compared to placebo, which indicates a rapid increase in the activity of bone-forming cells. This stimulation did not have any effect on reproductive function – the testosterone level in the volunteers did not change after the infusion of kisspeptin.
The second part of the study, conducted in collaboration with colleagues from the University of Southern Denmark, was performed in vitro: bone tissue cells taken from healthy volunteers and from patients operated on for a femoral fracture were treated with kisspeptin. The researchers found that the hormone not only stimulated the activity of osteoblasts, but also suppressed the activity of osteoclasts – bone-destroying cells. The fact is that most of the existing methods of treating osteoporosis eventually either inhibit or increase the activity of both types of bone cells. But kisspeptin, as the experiment showed, increases bone-forming activity and at the same time suppresses bone resorption. This feature gives kisspeptin a clear advantage as a potential treatment if the results are confirmed in subsequent studies, longer and larger, including those involving patients suffering from osteoporosis.
Kisspeptin is a natural hormone that plays an important role in reproduction, it has been studied in humans for many years and has not shown serious side effects. This is the first study to study the effect of kisspeptin on human bones. Previous studies have shown that it can be used in IVF and can increase sexual brain activity.
Article by A.N.Comninos et al. The Acute Effects of Kisspeptin Administration on Bone Metabolism in Healthy Men is published in the Journal of Clinical Endocrinology & Metabolism.
Aminat Adzhieva, portal "Eternal Youth" http://vechnayamolodost.ru based on the materials of Imperial College London: Kisspeptin hormone can enhance human bone activity.