Bioprinting with artificial ventilation

New biochernils deliver oxygen to 3D-printed tissues

Tatiana Matveeva, "Scientific Russia"

Scientists have developed a tissue engineering gel that can generate oxygen and deliver it to cells in 3D-printed tissues to keep them alive before blood vessels penetrate the tissue. The addition of oxygen to transplanted cells, formed during the decomposition of calcium peroxide (CPO), is an attractive approach to ensure cell viability. When this compound is used in three-dimensional bioprinting to create tissue implants, the ability of cells to repair tissue increases significantly, the press service of the Terasaki Institute of Biomedical Innovation (USA) reports. The results of the work are published in the journal Advanced Healthcare Materials (Erdem et al., 3D Bioprinting of Oxygenated Cell‐Laden Gelatin Methacryloyl Constructs).

Oxygen produced by calcium peroxide is delivered to cells in printed tissue structures during the entire time necessary for the full development of blood vessels. Then the blood vessels will be able to resume their oxygen delivery functions, and the cells will receive additional support necessary for the growth and repair of new tissue.

Thanks to the fact that oxygen can now be delivered to the implanted cells, scientists can improve the functionality of the tissue and ensure that the cells will take better root in the human body, for example, in patients who have suffered a heart attack. For some time in these patients, the heart did not receive enough oxygen, which can lead to damage to the heart tissue. Tissue implants printed with new biochernils can help not only increase the survival rate of affected heart cells, but also support the growth and formation of blood vessels. Also, similar tissues can be used for drug testing. 

Portal "Eternal youth" http://vechnayamolodost.ru