Genomics-2030
The Human Genome Institute predicted the development of genetics for 10 years ahead
Georgy Golovanov, Hi-tech+
An article published in the journal Nature (Green et. al., Strategic vision for improving human health at the Forefront of Genomics – VM) lists ten important achievements in the field of genomics, which, quite possibly, will occur by 2030 and will affect microbiology, medicine and everyday life. In particular, genetic tests will become a common practice available to millions of people, the same as a blood test today.
Since the appearance of the Human Genome project 30 years ago, genomics has penetrated into scientific research, medicine and even everyday life, turning into a field of knowledge that plays a huge role in the development of microbiology and oncology. Prenatal genetic tests, methods of genetic diagnosis of diseases and genetic passports that determine a person's DNA profile have appeared.
The US National Human Genome Research Institute has formulated in the document "Vision 2030" the most likely achievements of genomics that await us in the next ten years. And also outlined the obstacles facing the development of this science, and the measures necessary to overcome these barriers, writes Scientific American.
So, by 2030, we can witness the following achievements:
- Sequencing and analysis of the complete human genome will become a routine procedure for any laboratory.
- The biological functions of each gene will be known. For non-coding elements of the genome, such knowledge will become the rule, not the exception.
- The main properties of the epigenetic profile and the transcriptional outcome will become an integral part of predictive models of the influence of genotype on phenotype.
- The study of the human genome will go beyond traits based on historical and social constructs, such as race.
- Genome analysis will become publicly available to millions of people on a regular basis.
- Regular use of genetic information will become mainstream for all medical services, like a blood test.
- The clinical significance of all gene variants will become definite, the concept of "variant of indeterminate value" will disappear.
- The result of a complete genome sequencing with an informative annotation will, if desired, be available via the smartphone app.
- People of different genetic backgrounds will receive equal benefits from genomics.
- Breakthrough discoveries will lead to the emergence of therapies involving the genetic modification of dozens of hereditary diseases.
"In the Human Genome project, we mapped and sequenced the human genome in the best possible way, using the methods available at that time, starting with writing DNA sequences in a notebook by hand and faxing the pages to colleagues. Little by little, we discovered that our gradual evolution of approaches was, in fact, a revolution necessary for success. The same patience and perseverance is necessary to realize these predictions. Even if only two or three of them come true, we will achieve incredible things," said Eric Green, director of the Institute and one of the authors of the report.
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