27 February 2013

There are no "regeneration genes" in humans:(

People are not destined to grow new limbs

ABC MagazineScientists have always hoped that the ability of many amphibians to regenerate damaged tissues is a quality that has been inherent in all multicellular animals since ancient times.

This gave hope that the human body has a hidden potential for the regeneration of various organs. However, a recent study by scientists who analyzed the newt genome proves that this skill appeared in amphibians relatively recently. The results of their work are published in the journal Genome Biology (A de novo assembly of the newt transcriptome combined with proteomic validation identifies new protein families expressed during tissue regeneration).


On the left is a young newt, really red and leading a terrestrial lifestyle until about two years old;
on the right is an adult animal, which after returning to the water becomes gray–green and more spotted - VM.

The red spotted newt (Notophthalmus viridescens) is a tiny and graceful creature that nevertheless possesses amazing regenerative abilities. It is able to regrow the heart muscle, components of the central nervous system and even the lens of the eye. Thomas Braun from the Max Planck Institute for Heart and Lung Research in Germany and his colleagues hoped that these skills were embedded in the basic genetic program that is characteristic of all animals, including mammals. But research has shown that this is not the case.

Previous attempts to analyze the newt genome were unsuccessful due to its huge size - the newt genome is ten times larger than a human one. Brown and his colleagues decided to investigate the RNAs that occur during gene expression. These RNAs are known as transcriptomes. Using three different analytical techniques, the researchers gathered together all the information about newt transcriptomes and compiled the first catalog of its kind.

In total, there were 120 thousand RNA transcriptomes in the catalog, of which about 15 thousand encode protein synthesis. 826 RNAs of them are unique and are found only in the newt genome. Moreover, the expression of proteins by these genes in the original and regenerated tissue is very different, which suggests that these proteins are responsible for the restoration of damaged tissues. Consequently, no other vertebrate animal has such proteins.

Nevertheless, scientists do not give up. According to them, humanity can still benefit from the discovery of these proteins. Their detailed study can help at least slightly improve the more than modest self-healing ability inherent in some human organs. In particular, it can help in the development of new techniques for skin regeneration after wounds, burns and scars.

Portal "Eternal youth" http://vechnayamolodost.ru27.02.2013

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