Not only against aging cells
Senolytic drugs remove aging cells from the body, which contribute to the occurrence of age-related disorders and diseases. In a new study, the group of James Kirkland from the Mayo Clinic showed that aging cells secrete molecules that reduce the level of the geroprotector protein α-Klotho in many types of non-aging human cells. They transplanted aging cells into young mice and noted a decrease in the level of α-Klotho in brain tissue and urine, which led to a reduction in the life expectancy of the animals.
The researchers then formed three models with an increased accumulation of aging cells: healthy mice that aged naturally, young mice with obesity caused by excessive consumption of fatty foods, and young mice that had aging cells transplanted. Selective pharmacological removal of aging cells using a combination of senolytic drugs dasatinib and quercitin led to an increase in the level of α-Klotho in the urine, kidneys and brain of animals of each of the three groups and to an increase in life expectancy by 30%.
The result was confirmed in a clinical study: the administration of dasatinib together with quercitin to volunteers with idiopathic pulmonary fibrosis associated with cellular aging also led to an increase in the level of α-Klotho protein in urine.
Thus, the removal of aging cells using senolytics is a potential new feasible method for the treatment of age-related diseases accompanied by a decrease in the level of the geroprotective protein α-Klotho.
Article Y.Zhu et al. Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans is published in the journal EBioMedicine.
Aminat Adzhieva, portal "Eternal Youth" http://vechnayamolodost.ru .