Managed transgenics
Biologists have learned to control the activity of transgenes inserted into the genome using temperature, increasing the amount of the corresponding product depending on the heating of the cell. And they were able to precisely heat the cells with a beam of focused ultrasonic vibrations.
Hrit Munen from the Victor Segalen University of Bordeaux and his colleagues connected the luciferase gene encoding the "glowing" protein and the promoter (starting site) from the heat shock protein gene (HSP70). They inserted the resulting structure into the mouse genome and found that the glow was uneven in different organs and tissues. But this "basic" level of luciferase was much less than what was achieved by short-term targeted heating of cells to 43 o C.
Heat shock proteins, also known as chaperones, are involved in the restoration of intracellular structures after critical situations, be it temperature changes, high radiation background or pH fluctuations. Moreover, their formation increases sharply with an increase in temperature above the critical 43 degrees, which was used by scientists who separated the "thermosensitive" part from the chaperone gene, which simultaneously triggers DNA reading. The work of the scientists is published in the Proceedings of the National Academy of Sciences.
The relative safety of the method is also beyond doubt, because heating occurs due to high-intensity focused ultrasound under the control of MRI, capable of registering the "energy" of water molecules, including thermal.
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