Prolonging youth

Phytotherapeutic geroprotector

Scientists from Japan have found out that the folk drug rikkunsito, used for stomach pains, causes the body to produce the hunger hormone ghrelin, which, in turn, slows down aging by acting on the gene and protein SIRT1.

Eternal life for solving problems

Is it possible to put a person's consciousness in a test tube when it will be possible to create an avatar for people and why potentially possible immortality is not the most attractive scenario of human life.

Women with many children age more slowly

Canadian scientists conducted a study that showed that mothers with many children recover telomere length better.

Will methylene inhibit premature aging?

Small doses of methylene blue almost completely eliminate defects in the cells of patients with progeria, as well as eliminate age-related damage to healthy cells.

Epigenomics of longevity

A detailed study of the epigenome gives biologists the opportunity to get out of the fog of numerous theories of aging and more accurately understand the root causes of this phenomenon, as well as age-related diseases.

Another potential geroprotector

The antidepressant mianserin increases the total lifespan of C.elegans nematodes by a third, mainly due to the "young adult" phase.

Natural selection by property qualification

In the face of rapid scientific and technological progress, the super-rich figure out how to stop the aging process and spend serious money in an attempt to avoid death.

Asthma medicine rejuvenates the brain

Six weeks of taking the drug almost equalized the abilities of old and young rats. The drug also significantly reduced inflammation in the brain and enhanced neurogenesis in older rats.

Healing with young blood: the discussion continues

A group of physiologists from Harvard University has once again confirmed the important role of GDF11 (growth differentiation factor) and GDF8 (myostatin) proteins for the rejuvenation of the body.

Gene therapy of aging: experience for yourself

Elizabeth Perish, the head of the startup BioViva, became the first person in the world to receive genetic therapy for aging. According to Perish, we are talking about the activation of telomerase using viral vectors and the introduction of structures that stimulate the synthesis of follistatin.

238 genes that yeast lives longer without

Almost half of these genes that affect life expectancy are also found in mammalian DNA. In theory, all these DNA sites can be the "targets" that can be hit by life-prolonging drugs.

Slowing Down Aging: Are we ready? (4)

In the fourth and final part of the article, the remaining pharmacological and some other methods aimed at slowing down the aging process are considered.

References to the article "Geroprotectors: the most complete database"

Geroprotectors: the most complete database (3)

The data contained in Geroprotectors is subject to a Creative Commons license allowing their use in other analyses.

Geroprotectors: the most complete database (2)

Motivation to create a database Geroprotectors.org there was a desire to provide researchers interested in aging-slowing compounds with a universal resource that allows them to save a huge amount of time searching for data, studying literature and expert analysis.

Geroprotectors: the most complete database (1)

Geroprotectors is an easy-to-use public database containing information on more than 250 experiments in which more than 200 confirmed or potential geroprotectors were studied.

Scientists are preparing for the first clinical trials of the geroprotector

Doctors from Albert Einstein College announced the possible start of clinical trials of a drug that should slow down the aging of the human body, preliminary approval for the verification of which scientists have received from US regulatory authorities.

Stop aging

Some animals manage not to grow old; by examining them, it may be possible to rid a person of this scourge.

Geroprotectors for fruit flies and nematodes

Scientists from MIPT were able to increase the life span of fruit flies and C.elegans nematodes by adding carotenoids to their diet - substances contained in large quantities in brown algae and in orange fruits and vegetables, for example, carrots.

Rejuvenating apples for aging muscles

The weakening and atrophy of muscles in old age is caused by the transcription factor ATF4, the activity of which can be suppressed with the help of compounds contained in apples and green tomatoes.